ReviewCancer science2026
Ionizing Radiation and Ultraviolet Light Irradiation-Associated DNA Damage Increasing Genomic Instability Risk.
Review in Cancer science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cancer frequently develops in association with genomic instability, which includes massive induction of chromosomal structural variants (SVs) and single nucleotide variants (SNVs). SVs are typically caused by erroneous repair of DNA double-strand breaks (DSBs) and are tightly linked to cancer risk. Indeed, cancers often arise under DNA repair-deficient backgrounds such as BRCA1/2 mutations. However, many cancers exhibiting genomic instability occur without detectable defects in canonical repair pathways. The major exogenous risk factors include ionizing radiation (IR) and ultraviolet (UV) light, both of which induce multiple types of DNA damage. Long-standing questions are which specific types of DNA lesions induced by the irradiation contribute to genomic instability and how these lesions promote mutagenesis in cancer-driver genes. In this review, we summarize current knowledge regarding how IR and UV irradiation lead to genomic instability associated with mutation induction in cancer-driver genes.
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Registered trials
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