ArticleBMC complementary medicine and therapies2026
Chemical investigation and anti-trichinellosis activity of some ficus species leaves: in silico supported in vitro study.
Article in BMC complementary medicine and therapies, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundWorldwide, trichinellosis is a zoonotic illness. Albendazole (ALB), the nowadays anti-trichinellosis drug, has side effects and insufficient effectiveness. Ficus species have ubiquitous health benefits. The current work aimed to assess the in vitro anti-trichinellosis potential of seven Ficus species compared to the reference drug, ALB.
methodFourteen crude extracts from seven Ficus species (spp.) leaves were prepared using 70% methanol and aqueous solvents. Trichinella spiralis (T. spiralis) adult worms were isolated from infected mice, cultivated on a 24-well tissue culture plate, and subjected to the crude Ficus spp. extracts and ALB in culture media. The efficacy of the tested compounds was evaluated using parasitological analysis and electron microscopy (SEM). Preliminary phytochemical screening and total phenolic content were performed on Ficus spp. extracts showing the most promising effects. In addition, GC-MS analysis was performed on the most active extract to determine its chemical composition.
resultsThe parasitological analysis revealed that Ficus microcarpa (F.m) had the most promising effects, followed by Ficus sycomorus (F.s) and Ficus nitida (F.n) with the methanolic extracts' LC
conclusionThe current study emphasizes the promising potential of Ficus species, especially F.m, as natural sources for the development of antiparasitic agents for the therapy of trichinellosis.
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