ArticleClinical pharmacology and therapeutics2026
Triglyceride Polygenic Score Identifies Individuals Who May Respond Differently to Aspirin in Primary Prevention.
Article in Clinical pharmacology and therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
Low-dose aspirin is no longer routinely recommended for the primary prevention of cardiovascular disease in older adults due to a lack of net benefit over bleeding risk. We hypothesized that genetic subgroups may experience differential harm or benefit from aspirin therapy. To investigate this, we screened 572 polygenic scores (PGSs) for modification of aspirin's effect on major bleeding and major adverse cardiovascular events (MACE) in the Aspirin in Reducing Events in the Elderly (ASPREE) randomized, placebo-controlled trial of daily 100 mg aspirin. Participants were aged ≥70 years (≥65 years for US minorities) and free of cardiovascular disease, dementia, or physical disability at enrolment. Among participants with high-quality genotyping data (n = 13,571), PGS-aspirin interactions were tested using Cox proportional hazards models with Bonferroni correction for multiple testing. During a median follow-up of 4.6 years, 414 major bleeding events and 464 MACE occurred. A triglyceride-related PGS (PGS003144) significantly modified aspirin-associated bleeding (interaction P = 5.9 × 10
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