Evidence map›Paper›PMID 42601542›Full record

ArticleAnalytical and bioanalytical chemistry2026

Ultrasensitive miRNA-21 biosensing: a metal-free photoinduced ROMP strategy via 3'-end oxidation.

Yunna Li, Shijin Zhou, Zhidan Tian, Jinming Kong, Xueji Zhang

Abstract read
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In one paragraph

Article in Analytical and bioanalytical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yunna LiSchool of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing, 210094, Jiangsu, China.
Shijin ZhouSchool of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing, 210094, Jiangsu, China.
Zhidan TianDepartment of Pathology, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, Jiangsu, China. tianzhidan@foxmail.com.
Jinming KongSchool of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing, 210094, Jiangsu, China. j.kong@njust.edu.cn.
Xueji ZhangSchool of Biomedical Engineering, Shenzhen University Health Science Center, Shenzhen, 518060, China.

Funding

National Natural Science Foundation of China KQTD20221101093605019
6 · The paper itself

Abstract

MicroRNA-21 (miRNA-21) is frequently overexpressed in various solid tumors, making its reliable quantification important for cancer-related biomarker analysis. Herein, we report an electrochemical sensing strategy that integrates RNA 3'-end oxidation with metal-free photo-induced ring-opening metathesis polymerization (photo-ROMP) for miRNA-21 detection. After hybridization with a thiolated DNA probe immobilized on a gold electrode, the 3'-terminal cis-diol group of miRNA-21 was selectively oxidized by sodium periodate to generate reactive aldehyde groups. The vinyl ether initiator 3-aminopropanol vinyl ether (APVE) was subsequently anchored to the oxidized miRNA-21 through aldehyde-amine condensation followed by NaCNBH

Indexed as

3′-Hydroxyl oxidationElectrochemical biosensormiRNA-21Photo-ROMPSignal amplification

Identifiers

PMID42601542

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.