Article in Nature immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Nancy WangDepartment of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
M Zeeshan ChaudhryThe University of Queensland Frazer Institute, University of Queensland, Woolloongabba, Queensland, Australia.ORCID http://orcid.org/0000-0002-1372-4257
Peter T BellThe University of Queensland Frazer Institute, University of Queensland, Woolloongabba, Queensland, Australia.
Ellesandra C NoyeThe University of Queensland Frazer Institute, University of Queensland, Woolloongabba, Queensland, Australia.ORCID http://orcid.org/0000-0003-1300-5129
Abbey WaddingtonThe University of Queensland Frazer Institute, University of Queensland, Woolloongabba, Queensland, Australia.ORCID http://orcid.org/0009-0009-1663-4992
Junpeng YeThe University of Queensland Frazer Institute, University of Queensland, Woolloongabba, Queensland, Australia.
Jaring SchreuderThe University of Queensland Frazer Institute, University of Queensland, Woolloongabba, Queensland, Australia.ORCID http://orcid.org/0000-0002-7579-0006
Nicolas JacquelotDepartment of Biochemistry & Molecular Biology; Department of Microbiology, Immunology & Infectious Diseases; Riddell Centre for Cancer Immunotherapy, Arnie Charbonneau Cancer Institute, Arthur J.E. Child Comprehensive Cancer Centre, Calvin, Phoebe, and Joan Snyder Institute for Chronic Diseases, Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.ORCID http://orcid.org/0000-0003-0282-1892
Cyril SeilletWalter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Philip M HansbroCentre for Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, School of Life Sciences, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0002-4741-3035
Richard A StrugnellDepartment of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0003-0614-5641
Zewen Kelvin TuongIan Frazer Centre for Children's Immunotherapy Research, Child Health Research Centre, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0002-6735-6808
Gabrielle T BelzThe University of Queensland Frazer Institute, University of Queensland, Woolloongabba, Queensland, Australia. g.belz@uq.edu.au.ORCID http://orcid.org/0000-0002-9660-9587
Funding
Cancer Council NSW (Cancer Council New South Wales) R.G. 21-05Department of Education and Training | Australian Research Council (ARC) DP200101058, DP230101156Department of Education and Training | Australian Research Council (ARC) LF2023003065, DP200101058, DP230101156, DP200103110Department of Health | National Health and Medical Research Council (NHMRC) 1165443, 1122277, 1054925, 1135898, 2008542Department of Health | National Health and Medical Research Council (NHMRC) 2030699Department of Health | National Health and Medical Research Council (NHMRC) DP200103110
6 · The paper itself
Abstract
Microfold (M) cells transcytose luminal antigens to initiate mucosal adaptive immunity, but their role in organizing innate responses in Peyer's patches is unclear. Here we showed that Peyer's patch M cells organized an epithelial-group 3 innate lymphoid cell (ILC3) axis, establishing a spatial niche within the dome epithelium that drove ILC3 localization, proliferation and IL-22 production. We found that epithelial, but not hematopoietic, SPI-B was required for intestinal IgA responses to establish this niche. Single-cell profiling of intestinal SPI-B
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Peyer's patch M cells organize an epithelial niche that sustains group 3 innate lymphoid cells and IL-22. · full record | OpenQuestion