Evidence map›Paper›PMID 42601467›Full record

ArticlePediatric research2026

Anxiety and mood disorders from childhood to adulthood in very preterm and term-born individuals.

Nicole Tsalacopoulos, Rheanna M Mainzer, Sarah C H Thompson, Karli Treyvaud, Leona Pascoe, Lauren Pigdon, Thi-Nhu-Ngoc Nguyen, Jeanie L Y Cheong, Lex W Doyle, Terrie E Inder and 1 more

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Article in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Nicole TsalacopoulosDepartment of Paediatrics, Monash Children's Hospital, Monash University, Melbourne, VIC, Australia. Nicole.Tsalacopoulos@monash.edu.
Rheanna M MainzerClinical Epidemiology and Biostatistics Unit, Murdoch Children's Research Institute, Melbourne, VIC, Australia.
Sarah C H ThompsonSchool of Psychological Sciences, Monash University, Melbourne, VIC, Australia.
Karli TreyvaudSchool of Psychology and Public Health, La Trobe University, Melbourne, VIC, Australia.
Leona PascoeSchool of Psychological Sciences, Monash University, Melbourne, VIC, Australia.
Lauren PigdonClinical Sciences, Murdoch Children's Research Institute, Melbourne, VIC, Australia.
Thi-Nhu-Ngoc NguyenClinical Sciences, Murdoch Children's Research Institute, Melbourne, VIC, Australia.
Jeanie L Y CheongClinical Sciences, Murdoch Children's Research Institute, Melbourne, VIC, Australia.
Lex W DoyleClinical Sciences, Murdoch Children's Research Institute, Melbourne, VIC, Australia.
Terrie E InderCenter for Perinatal & Infant Research, Rady Children's Hospital of Orange County, Orange, CA, USA.
Peter J AndersonSchool of Psychological Sciences, Monash University, Melbourne, VIC, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVery preterm (VP) birth has been associated with higher rates of anxiety and mood disorders, but the emergence and persistence from childhood to adulthood is unknown. This study examined prevalence rates and early risk factors of these disorders in VP and term-born individuals.

methodsIn a prospective sample of VP (<30 weeks' gestation or birthweight <1250 g, n = 191) and term-born individuals (n = 69), anxiety and mood disorders were assessed using structured interviews at 7, 13 years and 20 years. Perinatal, neonatal and social environmental information was collected at birth and 2 years.

resultsRates of anxiety and mood disorders increased from childhood to adulthood, but only subtle differences were observed between VP and term-born groups. Among VP individuals, higher social risk at 2 years increased the odds of anxiety or mood disorder (OR 2.51, 95% CI: 1.18, 5.35).

conclusionsPrevalence of anxiety and mood disorders increased from childhood to young adulthood for both birth groups, with the largest between-group difference observed for anxiety disorder at 13 years. Higher social risk was the main risk factor for VP individuals. Early identification and support for families with higher social risk may reduce mental health difficulties in VP individuals. IMPACT: There is evidence that very preterm (VP) birth is associated with higher rates of anxiety and mood disorders, but how these conditions emerge and persist from childhood to adulthood is unknown. Rates for anxiety and mood disorders increase from childhood to adulthood, but the developmental trajectory for VP individuals is similar to that of term-born peers. Social risk factors consistently influence mental health outcomes across development. Early assessment and targeted support for VP individuals and families facing socio-economic disadvantage may promote positive long-term mental health outcomes.

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PMID42601467

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