Evidence map›Paper›PMID 42601420›Full record

ArticleNature biomedical engineering2026

Biomimetic zona pellucida-encapsulated islets for sustained glycaemic control in immunocompetent mice.

Kyungsene Lee, Xuelin Wang, Connie Wen, Yixun Wang, Jennifer Z Wang, Brandon Davis, James Coyne, Alexander L Mark, Chien-Wei Wu, Ana Aviles Vargas and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature biomedical engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Kyungsene LeeDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, PA, USA.
Xuelin WangDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, PA, USA.
Connie WenDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, PA, USA.
Yixun WangDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, PA, USA.
Jennifer Z WangDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, PA, USA.ORCID http://orcid.org/0009-0005-4245-0629
Brandon DavisDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, PA, USA.
James CoyneDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, PA, USA.
Alexander L MarkDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, PA, USA.ORCID http://orcid.org/0009-0000-9787-6970
Chien-Wei WuDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, PA, USA.ORCID http://orcid.org/0009-0002-6889-9684
Ana Aviles VargasDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, PA, USA.
Yuhong JiangDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, PA, USA.
Thomas I McDougalDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, PA, USA.
Selina Y LinDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, PA, USA.
Xiaojun Lance LianDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, PA, USA.
Hong ZhengThe Pennsylvania State University Cancer Institute, The Pennsylvania State University College of Medicine, Hershey, PA, USA.
Yuguo LeiDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, PA, USA.
Yong WangDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, PA, USA. yxw30@psu.edu.ORCID http://orcid.org/0000-0002-2244-1742

Funding

Molecularly regulated release of angiogenic factors from superporous hydrogelsR01HL122311 · NHLBI · PENNSYLVANIA STATE UNIVERSITY, THE · PI WANG, YONG · 2015 to 2023
$4.2M
Molecular Machines Mechanism and Structure (M3S) Training ProgramT32GM149417 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI William Olaf Hancock · 2023 to 2026
$1.8M
Three-dimensional One-step Aptamer Selection in the Non-fouling Macroporous HydrogelR01GM154105 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI Yong Wang, Na Xiong · 2024 to 2026
$1.4M
Non-covalent functionalization of collagen for growth factor delivery using bispecific aptamersR01EB035568 · NIBIB · PENNSYLVANIA STATE UNIVERSITY, THE · PI Yong Wang · 2024 to 2026
$1.3M
NHLBI NIH HHS R01 HL122311NIBIB NIH HHS R01 EB035568NIGMS NIH HHS R01 GM154105NIGMS NIH HHS T32 GM149417U.S. Department of Health & Human Services | National Institutes of Health (NIH) EB035568U.S. Department of Health & Human Services | National Institutes of Health (NIH) GM154105U.S. Department of Health & Human Services | National Institutes of Health (NIH) HL122311U.S. Department of Health & Human Services | National Institutes of Health (NIH) T32GM149417
6 · The paper itself

Abstract

Islet transplantation is a promising therapy for treating type 1 diabetes. Thin capsules, although offering numerous advantages over thicker ones in islet transplantation, pose persistent challenges for ensuring long-term cell protection. Here we show a biomimetic approach for cell protection using thin capsules, inspired by the biological development of the zona pellucida. A thin 20-μm hydrogel capsule is spontaneously generated on the cell surface with 100% encapsulation efficiency through aptamer-directed molecular recognition, crosslinking and hardening. The entire encapsulation process takes place droplet-free and stress-free under physiological conditions, without exposure to harsh factors or any loss of cellular viability or function. Immunocompetent diabetic mice receiving encapsulated allogeneic islets achieved normoglycaemia, with most sustaining it for more than 100 days.

Identifiers

PMID42601420
PMCPMC13602392

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.