Evidence map›Paper›PMID 42601409›Full record

Reviewnpj drug discovery2026

New paradigm of q-CAR drug development targeting disease-specific protein conformations.

Libin Ye

Abstract readReview
In one paragraph

Review in npj drug discovery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Libin YeDepartment of Molecular Biosciences, University of South Florida, Tampa, FL, USA. libinye@usf.edu.

Funding

The Role of Intermediate Conformations in G Protein-coupled Receptor SignalingR01GM149659 · NIGMS · UNIVERSITY OF SOUTH FLORIDA · PI Libin Ye · 2023 to 2026
$1.4M
The Role of G Protein-coupled Receptors in Red Tide Dinoflagellate BioluminescenceR21ES035378 · NIEHS · UNIVERSITY OF SOUTH FLORIDA · PI YE, LIBIN · 2023 to 2023
$407k
Department of Energy DE-AR0002095NIEHS NIH HHS R21 ES035378NIGMS NIH HHS 1R01GM149659NIGMS NIH HHS R01 GM149659
6 · The paper itself

Abstract

Drug discovery has progressed to using advanced AI-driven platforms. These systems rely heavily on static structures and overlook an essential aspect: protein motion-conformational transitions and local fluctuations-is essential for function, as "no motion, no function." Thus, this review discusses recent progress in measuring protein conformations and dynamics and introduces a new concept, "quantitative conformation-activity relationship (q-CAR)," aimed at developing drugs that target disease-specific protein conformations in the future.

Identifiers

PMID42601409
PMCPMC13476234

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.