Evidence map›Paper›PMID 42600621›Full record

ArticleMolecular cell2026

Selective decay of interferon mRNAs controls antiviral immunity and innate memory.

Rachel M Braun, Max B Ferretti, Jae Seung Lee, Jesse Miller, Lauren Castellana, Jorge Acuña, Kanupriya Whig, Lenka Dohnalová, Hélène C Descamps, Alex S Huber and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Rachel M BraunDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Biochemistry, Biophysics and Chemical Biology Graduate Group, University of Pennsylvania, Philadelphia, PA 19104, USA.
Max B FerrettiDepartment of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA 19104, USA.
Jae Seung LeeDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Jesse MillerDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Lauren CastellanaDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Jorge AcuñaDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Cell and Molecular Biology Graduate Group, University of Pennsylvania, Philadelphia, PA 19104, USA.
Kanupriya WhigDepartment of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA 19104, USA; High Throughput Screening Core, University of Pennsylvania, Philadelphia, PA 19104, USA.
Lenka DohnalováDepartment of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Hélène C DescampsDepartment of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Alex S HuberDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Hiromi MuramatsuDepartment of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Peter HewinsDepartment of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Yue LiDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Smita BhutdaDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Zienab EtwebiDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Mark DittmarDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Cell and Molecular Biology Graduate Group, University of Pennsylvania, Philadelphia, PA 19104, USA.
Thomasina CookDepartment of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
David C SchultzDepartment of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA 19104, USA; High Throughput Screening Core, University of Pennsylvania, Philadelphia, PA 19104, USA.
Perry J BlackshearMolecular and Cellular Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.
Kellie Ann JuradoDepartment of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Christoph A ThaissDepartment of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Norbert PardiDepartment of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Kristen W LynchDepartment of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA 19104, USA.
Sara CherryDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA 19104, USA; High Throughput Screening Core, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: cherrys@pennmedicine.upenn.edu.

Funding

TRAINING IN VIROLOGYT32AI007324 · NIAID · WISTAR INSTITUTE · PI Paul Bates, Matthew D. Weitzman · 1989 to 2026
$6.8M
Signal-Induced Regulation of Alternative RNA ProcessingR35GM118048 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI KRISTEN W LYNCH · 2016 to 2026
$6.6M
The role of pattern recognition and autophagy in innate anti-bunyaviral immunityR01AI150246 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI CHERRY, SARA · 2019 to 2023
$3.5M
Defining the functional interface between the ER and flavivirusesR01AI140539 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI CHERRY, SARA, DIAMOND, MICHAEL S · 2018 to 2022
$3.0M
Defining the role of microbiota-derived cyclic dinucleotides in priming antiviral immune defenses.R01AI152362 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI CHERRY, SARA · 2020 to 2024
$2.0M
Bill & Melinda Gates Foundation INV-018479NIAID NIH HHS R01 AI140539NIAID NIH HHS R01 AI150246NIAID NIH HHS R01 AI152362NIAID NIH HHS T32 AI007324NIGMS NIH HHS R35 GM118048
6 · The paper itself

Abstract

Homeostatic control of interferon (IFN) signaling is essential, as dysregulation leads to poor outcomes. While the stimuli-dependent induction of IFNs is well understood, less is known about how IFN mRNAs are maintained at low levels basally or rapidly returned to baseline post-stimulation. We find that selective post-transcriptional control of type I and type III IFN mRNAs by the RNA-binding specificity factor tristetraprolin (TTP) and mRNA decay machinery contributes to homeostatic control by negatively regulating IFN mRNAs at steady state and post-stimulation. Loss of this pathway leads to increased poly(A) tail length, stability, and translation. This increases expression of IFNs, potently blocking severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in vitro and in vivo. A human TTP variant associated with autoimmunity shows decreased TTP levels and increased IFN signaling, further demonstrating that regulation by this pathway impacts disease. Prolonged IFN signaling driven by transient loss of mRNA decay primes cells, inducing innate memory and providing long-term antiviral protection.

Indexed as

COVID-19Immunity, InnateImmunologic MemoryInterferonsRNA, MessengerRNA StabilityTristetraprolinAnimalsHEK293 CellsHumansMiceMice, Inbred C57BLMice, KnockoutSignal TransductionTrained ImmunityInterferonsRNA, MessengerTristetraprolinZFP36 protein, humanZfp36 protein, mousecoronavirusmRNA decaypost-transcriptional control of interferonprimingrespiratory infectiontargeted mRNA deadenylationtrained immunitytristetraprolin

Identifiers

PMID42600621
PMCPMC13479723

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.