Evidence map›Paper›PMID 42600046›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2026

Magnesium Attenuates Renal Senescence and Fibrosis With Reduced DNA Damage Response and H3K4me3 Enrichment at the p16

Makoto Matsubara, Kensuke Sasaki, Shigehiro Doi, Takeshi Ike, Maria Yoshida, Akira Takahashi, Yosuke Osaki, Naoki Ishiuchi, Aiko Okubo, Yujiro Maeoka and 3 more

Abstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Makoto MatsubaraDepartment of Nephrology, Hiroshima University Hospital, Hiroshima, Japan.
Kensuke SasakiDepartment of Nephrology, Hiroshima University Hospital, Hiroshima, Japan.ORCID https://orcid.org/0000-0001-5899-0885
Shigehiro DoiDepartment of Nephrology, Hiroshima University Hospital, Hiroshima, Japan.
Takeshi IkeDepartment of Nephrology, Hiroshima University Hospital, Hiroshima, Japan.
Maria YoshidaDepartment of Nephrology, Hiroshima University Hospital, Hiroshima, Japan.
Akira TakahashiDepartment of Nephrology, Hiroshima University Hospital, Hiroshima, Japan.
Yosuke OsakiDepartment of Nephrology, Hiroshima University Hospital, Hiroshima, Japan.
Naoki IshiuchiDepartment of Nephrology, Hiroshima University Hospital, Hiroshima, Japan.
Aiko OkuboDepartment of Nephrology, Hiroshima University Hospital, Hiroshima, Japan.
Yujiro MaeokaDepartment of Nephrology, Hiroshima University Hospital, Hiroshima, Japan.
Takuto ChibaDivision of Nephrology, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Ayumu NakashimaDepartment of Nephrology, Hiroshima University Hospital, Hiroshima, Japan.
Takao MasakiDepartment of Nephrology, Hiroshima University Hospital, Hiroshima, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Renal fibrosis is a final pathway leading to end-stage renal disease, with cellular senescence contributing to fibrosis and inflammation. Magnesium ions (Mg

Indexed as

Cellular SenescenceCyclin-Dependent Kinase Inhibitor p16DNA DamageHistonesKidneyKidney DiseasesMagnesiumPromoter Regions, GeneticAnimalsCells, CulturedcGAS-STING Signaling PathwayFibrosisMaleMiceMice, Inbred C57BLReperfusion InjuryCdkn2a protein, mouseCyclin-Dependent Kinase Inhibitor p16histone H3 trimethyl Lys4HistonesMagnesiumcGAS‐STING pathwayDNA damageepigeneticsinflammationkidney injurymagnesiumsenescence

Identifiers

PMID42600046
PMCPMC13475955

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.