Evidence map›Paper›PMID 42600011›Full record

ArticleScience advances2026

An octopamine-glutamate cotransmitting neuron gates aggressive escalation through layered inhibition in

Antoine Prunier, Lewis M Sherer, Mariana Da Silva, Samantha Chong, Léa Bihl, R Steven Stowers, Sarah J Certel, Séverine Trannoy

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Antoine PrunierResearch Center for Animal Cognition, Integrative Biology Center, Toulouse University, Toulouse, France.ORCID 0009-0009-1137-0115
Lewis M ShererDepartment of Neuroscience, Brown University, Providence, RI, USA.ORCID 0000-0001-5875-1737
Mariana Da SilvaResearch Center for Animal Cognition, Integrative Biology Center, Toulouse University, Toulouse, France.ORCID 0009-0007-2780-5895
Samantha ChongBarnard College, New York City, NY, USA.ORCID 0009-0005-4833-2914
Léa BihlResearch Center for Animal Cognition, Integrative Biology Center, Toulouse University, Toulouse, France.
R Steven StowersDepartment of Microbiology & Immunology, Montana State University, Bozeman, MT, USA.ORCID 0000-0002-1473-2478
Sarah J CertelDivision of Biological Science, Neuroscience Program, University of Montana, Missoula, MT, USA.ORCID 0000-0003-2039-2657
Séverine TrannoyResearch Center for Animal Cognition, Integrative Biology Center, Toulouse University, Toulouse, France.ORCID 0000-0002-5059-9846

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
Functional role of dual neurotransmitter usage in aggressionR01GM115510 · NIGMS · MONTANA STATE UNIVERSITY - BOZEMAN · PI Sarah J Certel, Karla R. Kaun · 2015 to 2026
$3.1M
NIGMS NIH HHS R01 GM115510NIH HHS P40 OD018537
6 · The paper itself

Abstract

Aggression is an evolutionarily conserved behavior essential for survival and reproduction, yet escalation to high-intensity forms entails substantial metabolic costs and injury risks, necessitating precise neural control. Using

Indexed as

AggressionDrosophila melanogasterGlutamic AcidNeuronsOctopamineAnimalsDrosophila ProteinsReceptors, GABA-AReceptors, Metabotropic GlutamateSynaptic TransmissionDrosophila ProteinsGlutamic AcidOctopamineRdl protein, DrosophilaReceptors, GABA-AReceptors, Metabotropic Glutamate

Identifiers

PMID42600011
PMCPMC13475639

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.