Evidence map›Paper›PMID 42600008›Full record

ArticleScience advances2026

Mechanism and plasticity of primitive pyroptosis.

Zhi Su, Man Huang, Jianhua Gan, Zhaoxiang He, Yuanyuan Wang, Yuanwei Zhang, Jiuxin Qu, Long Zhou, Changbin Chen, Yu Feng and 2 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zhi SuCollege of Life Science and Technology, Guangxi University, Nanning, Guangxi 53004, China.ORCID 0009-0000-3767-4138
Man HuangDepartment of General Intensive Care Unit of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.ORCID 0000-0002-0842-2254
Jianhua GanDepartment of Biochemistry and Biophysics, School of Life Science, Fudan University, Shanghai 200433, China.ORCID 0000-0002-8438-8852
Zhaoxiang HeDepartment of Biophysics, Zhejiang University School of Medicine, Hangzhou 310058, China.ORCID 0009-0005-9553-8106
Yuanyuan WangShanghai Institute of Immunity and Infection, Chinese Academy of Sciences, Shanghai 200031, China.ORCID 0000-0001-7464-7446
Yuanwei ZhangJiangsu Key Laboratory for Pathogens and Ecosystems, Jiangsu Engineering and Technology Research Center for Microbiology, College of Life Sciences, Nanjing Normal University, Nanjing 210023, China.ORCID 0000-0003-0854-6123
Jiuxin QuDepartment of Clinical Laboratory, Shenzhen Third People's Hospital, Shenzhen 518112, China.ORCID 0000-0003-1061-2353
Long ZhouDepartment of Biophysics, Zhejiang University School of Medicine, Hangzhou 310058, China.ORCID 0000-0002-1864-8951
Changbin ChenShanghai Institute of Immunity and Infection, Chinese Academy of Sciences, Shanghai 200031, China.
Yu FengDepartment of Biophysics, Zhejiang University School of Medicine, Hangzhou 310058, China.ORCID 0000-0003-4239-8320
Zheng-Guo HeCollege of Life Science and Technology, Guangxi University, Nanning, Guangxi 53004, China.ORCID 0000-0003-0945-4095
Youjun FengDepartment of General Intensive Care Unit of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.ORCID 0000-0001-8083-0175

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pyroptosis is a proinflammatory form of regulated cell death across the tree of life. The gasdermin (GSDM) protein family functions as an evolutionarily conserved executioner of pyroptotic cell death by forming membrane pores. As the canonical activation mechanism, proteolytic cleavage drives the formation of GSDM pores. In contrast to the well-studied modern GSDM-directed pyroptotic pathway, biochemical mechanisms of primitive GSDM pores are poorly understood. Here, we functionally characterize two primitive GSDM variants with cytotoxicity, one of which is a bacterial homolog (termed bGSDM) from

Indexed as

PyroptosisBacterial ProteinsCryoelectron MicroscopyFungal ProteinsModels, MolecularPodosporaBacterial ProteinsFungal Proteins

Identifiers

PMID42600008
PMCPMC13475620

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.