Evidence map›Paper›PMID 42599887›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2026

The Src-Family Kinases Hck, Fgr and Lyn Drive Immune Complex-Mediated Glomerulonephritis Through the Syk Tyrosine Kinase.

Lukács S Lesinszki, Dorottya Deli, Lili K Boldizsár, Áron Pánczél, Attila Fintha, Michael G Robson, Attila Mócsai

Abstract read
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Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lukács S LesinszkiDepartment of Physiology, Semmelweis University School of Medicine, Budapest, Hungary.ORCID https://orcid.org/0000-0003-0730-9572
Dorottya DeliDepartment of Physiology, Semmelweis University School of Medicine, Budapest, Hungary.
Lili K BoldizsárDepartment of Physiology, Semmelweis University School of Medicine, Budapest, Hungary.
Áron PánczélDepartment of Physiology, Semmelweis University School of Medicine, Budapest, Hungary.ORCID https://orcid.org/0000-0003-1153-4844
Attila FinthaDepartment of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary.
Michael G RobsonDepartment of Inflammation Biology, School of Immunology and Microbial Sciences, King's College London, London, UK.
Attila MócsaiDepartment of Physiology, Semmelweis University School of Medicine, Budapest, Hungary.ORCID https://orcid.org/0000-0002-0512-1157

Funding

Hungarian Academy of Sciences LP2024-16/2024HUN-REN Hungarian Research Network 0207007Nemzeti Kutatási Fejlesztési és Innovációs Hivatal (NKFI) HU-RIZONT-2024-00055Nemzeti Kutatási Fejlesztési és Innovációs Hivatal (NKFI) K_146160Nemzeti Kutatási Fejlesztési és Innovációs Hivatal (NKFI) TKP2021-EGA-24Nemzeti Kutatási Fejlesztési és Innovációs Hivatal (NKFI) TKP2021-EGA-29
6 · The paper itself

Abstract

While immune complex-mediated glomerulonephritis causes severe kidney dysfunction in diseases like lupus nephritis, the signaling pathways involved are poorly understood. Here we tested the role of the Src-family kinases Hck, Fgr and Lyn, primarily expressed in innate immune cells, in immune complex-mediated glomerulonephritis. Hck, Fgr and Lyn expression increased in human lupus nephritis, as well as in mouse nephrotoxic nephritis triggered by sheep antiserum against mouse glomerular components (nephrotoxic serum). Nephrotoxic serum induced robust albuminuria, serum creatinine level increase, hematuria and ascites in wild-type but not in Hck

Indexed as

Antigen-Antibody ComplexGlomerulonephritisProto-Oncogene Proteins c-hcksrc-Family KinasesSyk KinaseAnimalsFemaleHumansLupus NephritisMiceMice, Inbred C57BLMice, KnockoutProto-Oncogene ProteinsSignal TransductionAntigen-Antibody ComplexHck protein, mouselyn protein-tyrosine kinaseProto-Oncogene Proteinsproto-oncogene proteins c-fgrProto-Oncogene Proteins c-hcksrc-Family KinasesSyk KinaseSyk protein, mouseglomerulonephritisimmune complexinflammationsignalingSrc‐family kinasestransgenic mice

Identifiers

PMID42599887
PMCPMC13475817

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.