Evidence map›Paper›PMID 42599804›Full record

ArticleCell reports2026

Lineage tracing reveals a shared cellular origin for supraclavicular brown and inguinal beige adipocytes.

Yali Ran, Kai Zhang, Yi-Ting Shen, Qianxing Mo, Ziyi Wang, Hari Krishna Yalamanchili, Sharon John, Mari Kogiso, Xia Gao, Chunmei Wang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Yali RanChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.
Kai ZhangCell Facility, Haematology Oncology, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.
Yi-Ting ShenChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.
Qianxing MoDepartment of Biostatistics & Bioinformatics, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
Ziyi WangChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.
Hari Krishna YalamanchiliChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA.
Sharon JohnChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.
Mari KogisoChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.
Xia GaoChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.
Chunmei WangChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.
Tanvi SinhaCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA.
Brian L BlackCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA.
Miao-Hsueh ChenChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: miao-hsueh.chen@bcm.edu.

Funding

Genetic and Functional Investigation of Supraclavicular Brown Adipose TissueR01DK116899 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI CHEN, MIAOHSUEH · 2019 to 2022
$1.4M
Generation and analysis of mouse models to define the roles of the ALS-associated factor Zfp106/ZNF106 in neurodegenerationR01NS126499 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Brian L Black · 2024 to 2026
$1.2M
Transcriptional control of endocardial-specific gene expressionR01HL177462 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Brian L Black · 2025 to 2026
$1.1M
Understanding methionine metabolism and its therapeutic potential in cancerR00CA237618 · NCI · BAYLOR COLLEGE OF MEDICINE · PI GAO, XIA · 2022 to 2024
$747k
NCI NIH HHS R00 CA237618NHLBI NIH HHS R01 HL177462NIDDK NIH HHS R01 DK116899NINDS NIH HHS R01 NS126499
6 · The paper itself

Abstract

The metabolic importance of brown adipose tissue (BAT) has been recognized, but its origins, particularly supraclavicular BAT (scBAT), remain unclear. Here, we traced scBAT to Mef2c-anterior heart field (AHF)-marked cells. Mef2c-AHF-marked cells isolated from scBAT can spontaneously differentiate into brown adipocytes, express mesenchymal stem cell markers, and can be isolated from the stromal-vascular fraction (SVF) of wild-type scBAT as [CD31

Indexed as

beige adipocytesCP: developmental biologyCP: metabolismlineage tracingscBATsupraclavicular brown adipose tissue

Identifiers

PMID42599804
PMCPMC13641681

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.