Evidence map›Paper›PMID 42599802›Full record

ArticleCell reports2026

TTN

Sagar Bhatta, Alayna Grzybowski, Gion Ortiz, Marcello DiStasio

Abstract read
In one paragraph

Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sagar BhattaDepartment of Ophthalmology and Visual Science, Yale School of Medicine, New Haven, CT, USA.
Alayna GrzybowskiDepartment of Pathology Yale School of Medicine, New Haven, CT, USA.
Gion OrtizProgram in Forensic Science, University of New Haven, New Haven, CT, USA.
Marcello DiStasioDepartment of Ophthalmology and Visual Science, Yale School of Medicine, New Haven, CT, USA; Department of Pathology Yale School of Medicine, New Haven, CT, USA. Electronic address: marcello.distasio@yale.edu.

Funding

Mechanisms of proinflammatory glial activation in retinal degenerationK08EY033013 · NEI · YALE UNIVERSITY · PI Marcello Michael DiStasio · 2024 to 2026
$842k
NEI NIH HHS K08 EY033013
6 · The paper itself

Abstract

The choroid plexus (ChP) regulates cerebrospinal fluid homeostasis and immune surveillance, but its cellular organization and response to Alzheimer's disease (AD) remain incompletely defined. Here, we integrate single-nucleus RNA sequencing with spatial transcriptomics to generate a high-resolution atlas of the adult human ChP. We identify all major epithelial, stromal, and immune populations and resolve heterogeneity within macrophages, including a distinct subset expressing the giant protein TTN. These TTN

Indexed as

Alzheimer’s diseaseborder-associated macrophageschoroid plexusCP: neurosciencemechanobiologysingle-nucleus RNA sequencingspatial transcriptomicstitin (TTN)

Identifiers

PMID42599802
PMCPMC13575895

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.