Evidence map›Paper›PMID 42599744›Full record

ArticleClinical transplantation2026

The Benefit of Sequential Normothermic Regional Perfusion and Hypothermic Machine Perfusion in Kidney Transplantation From Donation After Circulatory Death Donors.

Toshihiro Nakayama, Sue J Fu, Antony M Attia, Daniel J Ahn, Thomas A Pham, Marc L Melcher, Kliment K Bozhilov, Kazunari Sasaki

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical transplantation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Toshihiro NakayamaStanford Transplant Outcomes Research Center (STORC), Division of Abdominal Transplantation, Stanford University Medical Center, Stanford, California, USA.ORCID https://orcid.org/0000-0001-8216-0371
Sue J FuStanford Transplant Outcomes Research Center (STORC), Division of Abdominal Transplantation, Stanford University Medical Center, Stanford, California, USA.ORCID https://orcid.org/0000-0003-4789-4876
Antony M AttiaStanford Transplant Outcomes Research Center (STORC), Division of Abdominal Transplantation, Stanford University Medical Center, Stanford, California, USA.ORCID https://orcid.org/0009-0003-0705-3076
Daniel J AhnStanford Transplant Outcomes Research Center (STORC), Division of Abdominal Transplantation, Stanford University Medical Center, Stanford, California, USA.ORCID https://orcid.org/0000-0003-4243-3325
Thomas A PhamStanford Transplant Outcomes Research Center (STORC), Division of Abdominal Transplantation, Stanford University Medical Center, Stanford, California, USA.ORCID https://orcid.org/0009-0000-4526-6353
Marc L MelcherStanford Transplant Outcomes Research Center (STORC), Division of Abdominal Transplantation, Stanford University Medical Center, Stanford, California, USA.ORCID https://orcid.org/0000-0002-7185-4383
Kliment K BozhilovStanford Transplant Outcomes Research Center (STORC), Division of Abdominal Transplantation, Stanford University Medical Center, Stanford, California, USA.ORCID https://orcid.org/0000-0003-3547-863X
Kazunari SasakiStanford Transplant Outcomes Research Center (STORC), Division of Abdominal Transplantation, Stanford University Medical Center, Stanford, California, USA.ORCID https://orcid.org/0000-0003-2514-5778

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNormothermic regional perfusion (NRP) is associated with improved posttransplant outcomes in donation after circulatory death (DCD) kidney transplantation. It remains unknown whether hypothermic machine perfusion (HMP) offers additional benefits over static cold storage (SCS) during transport.

methodsAll adult kidney-only transplantations from DCD donors procured by NRP in the OPTN data (10/1/2020-6/30/2025) were identified. Primary exposure was preservation method during transport: NRP combined with HMP (NRP+HMP) or SCS (NRP+SCS). One-to-two propensity score matching (PSM) was performed on fifteen donor and recipient factors. Primary outcomes included delayed graft function (DGF), posttransplant length of stay (LOS), and estimated glomerular filtration rate (eGFR) at 6 months posttransplant. Secondary outcomes were one-year graft and patient survival.

resultsAmong 4792 NRP cases, HMP was utilized in 85.1%, with its use increasing over time. After 1:2 PSM (685 NRP+SCS matched to 1262 NRP+HMP), NRP+HMP was associated with significantly lower DGF (23.3% vs. 30.5%, p < 0.01). Median LOS (4.0 days in both groups, p = 0.07), 6-month eGFR (58.5 vs. 60.1 mL/min/1.73m

conclusionThe adoption of HMP after NRP has increased substantially in the United States and was associated with reduced DGF, but no difference was observed for LOS, 6-month eGFR, graft survival, and patient survival. These findings support the routine use of HMP after NRP.

Indexed as

Delayed Graft FunctionHypothermia, InducedKidney TransplantationOrgan PreservationPerfusionTissue and Organ ProcurementTissue DonorsAdultFemaleFollow-Up StudiesGlomerular Filtration RateGraft SurvivalHumansKidney Function TestsMaleMiddle Agedkidney transplantationnormothermic regional perfusionthe United Network for Organ Sharing (UNOS)

Identifiers

PMID42599744
PMCPMC13475596

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.