Evidence map›Paper›PMID 42599583›Full record

ArticleAntonie van Leeuwenhoek2026

Immunization with PLGA-encapsulated recombinant staphylococcal enterotoxin C confers protection against intramammary Staphylococcus aureus challenge in a murine mastitis model.

Desh Deepak, Preena Prasanna, Radhika Vaidya, Syed Atif Ali, Nongthombam Boby, Banaja Kanta Pati, Ujjwal Kumar De, Med Ram Verma, Monalisa Sahoo, Pallab Chaudhury and 1 more

Abstract read
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In one paragraph

Article in Antonie van Leeuwenhoek, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Desh DeepakDivision of Medicine, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, 243122, India.
Preena PrasannaDivision of Medicine, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, 243122, India. preenap@kvasu.ac.in.ORCID https://orcid.org/0000-0001-6488-3621
Radhika VaidyaDivision of Medicine, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, 243122, India.
Syed Atif AliDivision of Bacteriology and Microbiology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, 243122, India.
Nongthombam BobyDivision of Veterinary Biotechnology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, 243122, India.
Banaja Kanta PatiDivision of Medicine, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, 243122, India.
Ujjwal Kumar DeDivision of Medicine, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, 243122, India.
Med Ram VermaDivision of Livestock Economics, Statistics and Information Technology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, 243122, India.
Monalisa SahooDivision of Pathology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, 243122, India.
Pallab ChaudhuryDivision of Bacteriology and Microbiology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, 243122, India.
Reena MukherjeeDivision of Medicine, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, 243122, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mastitis caused by Staphylococcus aureus remains a significant challenge to control due to increasing antimicrobial resistance and the limited efficacy of existing vaccines. Staphylococcal enterotoxin C (SEC) is a critical virulence factor and a highly immunogenic determinant in S. aureus strains frequently isolated from bovine mastitis cases. In this study, we evaluated the immunogenicity and protective efficacy of recombinant SEC (rSEC) encapsulated within poly(lactide-co-glycolide) microparticles (PLGA-rSEC) using a murine mastitis model. Immunization with PLGA-rSEC induced significantly higher serum IgG responses (OD

Indexed as

EnterotoxinsMastitisStaphylococcal InfectionsStaphylococcal VaccinesStaphylococcus aureusAnimalsAntibodies, BacterialDisease Models, AnimalFemaleImmunizationImmunoglobulin GLactic AcidMammary Glands, AnimalMiceMice, Inbred BALB CPolyglycolic AcidAntibodies, Bacterialenterotoxin C, staphylococcalEnterotoxinsImmunoglobulin GLactic AcidPolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerProtein Subunit VaccinesRecombinant ProteinsStaphylococcal VaccinesVaccines, SyntheticBacterinC-reactive proteinIgGIL-10PLGA microparticles

Identifiers

PMID42599583

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.