ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2026
Long-term safety and efficacy of suprachoroidal ESNOPER CLIP
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo evaluate the long-term hypotensive efficacy and safety of the ESNOPER CLIP
methodsPatients who underwent NPDS and suprachoroidal ESNOPER CLIP
results132 eyes (mean age 68.8 ± 8.9 years) were included. BCVA remained similar after surgery (0.73 ± 0.27 decimal preoperatively and 0.74 ± 0.29 after 5 years, p = 0.723). IOP experienced a significant improvement compared to preoperative values (20.7 ± 8.0 vs. 13.0 ± 4.2 mmHg), with a mean number of topical hypotensive medications significantly dropping from 2.63 ± 0.82 to 0.64 ± 0.95 after 5 years. Visual field MD did not significantly change. Four microperforations were registered as intraoperative complications (3%) and 49% needed goniopuncture during follow-up. Needling rate was 26%. After 5 years, complete and qualified success rates were 58% and 88% for IOP≤21mmHg threshold, 59% and 85% for IOP≤18mmHg threshold, and 49% and 60% for IOP≤15mmHg threshold, respectively.
conclusionsNPDS with the ESNOPER CLIP KEY MESSAGES: WHAT IS KNOWN : Non-penetrating deep sclerectomy is considered a safe and effective filtering procedure with potentially lower complication rates compared to traditional trabeculectomy. The uveoscleral Esnoper Clip implant used in non-penetrating deep sclerectomy has shown effective and safe results, although available evidence is limited to follow-ups of up to 2 years. WHAT IS NEW: This is the first study reporting 5-year outcomes of the Esnoper Clip implant, including assessment of its performance when combined with cataract surgery. Non-penetrating deep sclerectomy enhanced with the suprachoroidal Esnoper Clip implant is safe and effective in maintaining a reduction of both, intraocular pressure and the number of topical hypotensive medications, in the long term. Non-penetrating deep sclerectomy and Esnoper Clip implantation combined with phacoemulsification is a suitable approach for managing glaucoma patients with concurrent cataract.
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