Evidence map›Paper›PMID 42599302›Full record

ArticleAnalytical and bioanalytical chemistry2026

U-shaped fiber-optic biosensor with gold nanoparticle-assisted signal amplification for allergy-related biomarker detection.

Che-Hao Tseng, Lin-Chia Chen, Li-Chen Su, Ja-An Annie Ho, Ying-Feng Chang

Abstract read
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In one paragraph

Article in Analytical and bioanalytical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Che-Hao TsengDepartment of Biochemical Science and Technology, National Taiwan University, Taipei, 106319, Taiwan.
Lin-Chia ChenDepartment of Biochemical Science and Technology, National Taiwan University, Taipei, 106319, Taiwan.
Li-Chen SuOrganic Electronics Research Center, Ming Chi University of Technology, New Taipei City, 243303, Taiwan.
Ja-An Annie HoDepartment of Biochemical Science and Technology, National Taiwan University, Taipei, 106319, Taiwan.
Ying-Feng ChangDepartment of Biochemical Science and Technology, National Taiwan University, Taipei, 106319, Taiwan. yfchang@mail.cgu.edu.tw.

Funding

Ministry of Education, Taiwan Higher Education Sprout Project: 113L895204Ministry of Education, Taiwan Higher Education Sprout Project: 114L893404National Science and Technology Council 109-2113-M-002-007-MY3National Science and Technology Council 112-2113-M-002-026-MY3National Science and Technology Council 114-2221-E-182-035
6 · The paper itself

Abstract

Achieving high analytical sensitivity in fiber-optic biosensors frequently involves a trade-off between signal intensity and structural integrity, particularly when relying on cladding-removal strategies or complex grating inscription processes. Here, we present a cladding-preserved U-shaped fiber-optic biosensor designed to address this long-standing trade-off through simulation-guided geometry optimization and a gold nanoparticle (GNP)-assisted attenuation-based amplification strategy. Optical simulations were first used to identify an optimal bend radius of 5 mm predicted to maximize evanescent-field interaction while fully retaining the fiber's protective cladding. The sensor surface was then functionalized using optimized poly(ethyleneimine) (PEI) and glutaraldehyde (GA) chemistry, followed by a multilayer immunoassay with GNP-streptavidin conjugates for signal amplification. The fabricated 5 mm sensor demonstrated a refractive-index resolution of 10⁻

Indexed as

Cladding-preservedEvanescent waveGold nanoparticleU-shaped fiber-optic biosensor

Identifiers

PMID42599302

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.