Evidence map›Paper›PMID 42599300›Full record

ArticleUrolithiasis2026

EP3 receptor mediates calcium oxalate kidney stone formation via Ca²⁺/AKT and necroinflammation.

Jing Leng, Yang Li, Xueqing Tang, Zhijie Song, Hangyu Lv, Huiying Han, Na Wen, Jinghang Fan, Xin Zhang A, Lin Zhang and 5 more

Abstract read
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In one paragraph

Article in Urolithiasis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jing Leng *Department of Cell Biology and Genetics, Shenyang Medical College, Shenyang, 110034, China.
Yang Li *Department of Cell Biology and Genetics, Shenyang Medical College, Shenyang, 110034, China.
Xueqing Tang *Department of Cell Biology and Genetics, Shenyang Medical College, Shenyang, 110034, China.
Zhijie SongDepartment of Cell Biology and Genetics, Shenyang Medical College, Shenyang, 110034, China.
Hangyu LvDepartment of Cell Biology and Genetics, Shenyang Medical College, Shenyang, 110034, China.
Huiying HanDepartment of Cell Biology and Genetics, Shenyang Medical College, Shenyang, 110034, China.
Na WenDepartment of Cell Biology and Genetics, Shenyang Medical College, Shenyang, 110034, China.
Jinghang FanDepartment of Cell Biology and Genetics, Shenyang Medical College, Shenyang, 110034, China.
Xin Zhang ADepartment of Cell Biology and Genetics, Shenyang Medical College, Shenyang, 110034, China.
Lin ZhangDepartment of Cell Biology and Genetics, Shenyang Medical College, Shenyang, 110034, China.
Xin Zhang BDepartment of Cell Biology and Genetics, Shenyang Medical College, Shenyang, 110034, China.
Fabin ZhouDepartment of Cell Biology and Genetics, Shenyang Medical College, Shenyang, 110034, China.
Tao GuoDepartment of Cell Biology and Genetics, Shenyang Medical College, Shenyang, 110034, China.
Qing LiuShenyang Red-cross Hospital, 389 Zhongshan Rd, Shenyang, 110013, China.
Bing GaoDepartment of Cell Biology and Genetics, Shenyang Medical College, Shenyang, 110034, China. gaobingdr@hotmail.com.

Funding

Doctoral Research Startup Project of the Liaoning Provincial Science and Technology Plan Joint Fund 2023-BSBA-292National Natural Science Foundation of China 82300865National Natural Science Foundation of China 82470798
6 · The paper itself

Abstract

Kidney stone disease is a prevalent urological condition with rising incidence and high recurrence rates, yet effective pharmacological interventions remain lacking [1] Prostaglandin E₂ (PGE₂) and its receptor EP3 have been implicated in inflammatory kidney injury [1-3], but their role in nephrolithiasis is unclear. This study investigates the role and mechanism of EP3 in calcium oxalate (CaOx) stone formation using in vitro and in vivo models. EP3 expression was significantly upregulated in CaOx-stimulated human renal tubular epithelial cells (HK-2) and in kidney tissues of glyoxylate-induced nephrolithiasis mice. Treatment with the EP3 antagonist DG041 in vitro reduced crystal adhesion, decreased HMGB1 release, and suppressed IL-6 and TNF-α expression. Mechanistically, EP3 antagonism inhibited aberrant intracellular Ca

Indexed as

Calcium OxalateKidney CalculiNephrolithiasisProto-Oncogene Proteins c-aktReceptors, Prostaglandin E, EP3 SubtypeAnimalsCalciumCell LineDisease Models, AnimalHMGB1 ProteinHumansInflammationMaleMiceTumor Necrosis Factor-alphaCalciumCalcium OxalateHMGB1 ProteinProto-Oncogene Proteins c-aktReceptors, Prostaglandin E, EP3 SubtypeTumor Necrosis Factor-alphaCalcium oxalateEP3 receptorKidney stonesNecroinflammation

Identifiers

PMID42599300

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.