Evidence map›Paper›PMID 42599205›Full record

ArticleInternational journal for quality in health care : journal of the International Society for Quality in Health Care2026

Improving surgical patients' safety in African hospitals: exploring healthcare professionals' experiences of Phase 1 of the '5Rs to Rescue' programme.

Charles Fadipe, Rowan Duys, Gillian J Bedwell, Pierre Barker, Godfrey Barabona, Bruce M Biccard, Ryan Ellis, Adam Hewit-Smith, Fitsum Kilfe, Marianne E McPherson and 6 more

Abstract read
In one paragraph

Article in International journal for quality in health care : journal of the International Society for Quality in Health Care, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

16 authors.

Charles FadipeCritical Care and Perioperative Medicine Research Group, WHRI, Queen Mary University of London, London, United Kingdom.
Rowan DuysDepartment of Anaesthesia and Perioperative Medicine, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.
Gillian J BedwellDepartment of Anaesthesia and Perioperative Medicine, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.
Pierre BarkerInstitute for Healthcare Improvement (IHI), Boston, MA, United States.ORCID 0000-0002-0963-0899
Godfrey BarabonaEmergency Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Bruce M BiccardDepartment of Anaesthesia and Perioperative Medicine, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.
Ryan EllisCritical Care and Perioperative Medicine Research Group, WHRI, Queen Mary University of London, London, United Kingdom.
Adam Hewit-SmithNuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-6019-2441
Fitsum KilfeGlobal Surgery Division, Department of Surgery, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Marianne E McPhersonInstitute for Healthcare Improvement (IHI), Boston, MA, United States.
Busisiwe MraraAnaesthesiology and Critical Care, Walter Sisulu University, Mthatha, Eastern Cape, South Africa.
Ezile NiniseAnaesthesiology and Critical Care, Walter Sisulu University, Mthatha, Eastern Cape, South Africa.
Rupert M PearseCritical Care and Perioperative Medicine Research Group, WHRI, Queen Mary University of London, London, United Kingdom.
Rafael ShayoEmergency Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Timothy J StephensCritical Care and Perioperative Medicine Research Group, WHRI, Queen Mary University of London, London, United Kingdom.
APPRISE Investigators

Funding

Global Health Group funding NIHR133850UK National Institute of Health Research
6 · The paper itself

Abstract

backgroundThe mortality rate of surgical patients in Africa is twice the global average. Pan-African studies have identified that this excess mortality is driven by deaths arising from postoperative complications. Preventable deaths can be reduced with enhanced monitoring in the postoperative period. This study reports on the first of a two-phase Quality Improvement (QI) programme, '5 Rs to Rescue', designed to reduce failure to rescue for surgical patients in Africa.

methodsUsing a QI approach, we co-produced a failure to rescue intervention with stakeholders across four African countries (Ethiopia, South Africa, Tanzania, and Uganda). These initial interventions were as follows: (i) Risk assessment using a validated tool, (ii) Recognition of patient deterioration using an early warning system (EWS), (iii) Response to patient deterioration (using locally defined protocols, (iv) Reassessment using an EWS, and (v) Reflection on care provided. These were tested and refined in clinical practice at nine hospitals through QI approaches. We interviewed frontline staff, project leaders, and QI advisors at the end of Phase 1 to learn from their experience to refine the intervention prior to Phase 2. Deductive thematic analysis was used, sensitized by constructs from the Consolidated Framework for Implementation Research (CFIR).

resultsWe interviewed 11 frontline staff, seven national project leads and five QI advisors. From the CFIR-based coding, two cross-cutting, higher-order themes were developed to describe the participant's experience. Theme 1 centred around the substantial relational work involved in leading the 5Rs project. Surgeons reported the recurrent communication required to engage, train, and motivate all the necessary stakeholders. Surgical and nursing hierarchies were poorly linked in many settings, initially hampering these relational efforts. Theme 2 centred on the complexity of the 5Rs tools being introduced into complex, and already overstretched systems. A long period was required for nurses and doctors to become familiarized with the proposed '5Rs' tools. Although their value was broadly accepted, not all tools were a good fit for all the project settings. Potential solutions to overcome barriers identified in Phase 2 included a longer QI programme, more emphasis on involving nurse leaders and selection of a less complicated 'EWS' for detecting patient deterioration.

conclusionDeveloping a multifaceted intervention that fits within complex, resource-limited contexts is a major challenge for efforts to improve patient care. This Phase 1 evaluation has provided actionable learning, targeting specific barriers, to be incorporated into an improved failure to rescue QI programme being developed in Phase 2.

Indexed as

Failure to Rescue, Health CareHealth PersonnelPatient SafetyPostoperative ComplicationsQuality ImprovementAfricaHumansResource-Limited SettingsRisk AssessmentAfricalow- and middle-income countryperioperative carequality improvementsurgery

Identifiers

PMID42599205
PMCPMC13503004

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.