ArticleJournal of separation science2026
Development and Validation of a QuEChERS-LC-MS/MS Method for Simultaneous Determination of Four Direct Oral Anticoagulants in Citrate Plasma and Quantitative Dried Plasma Spots.
Article in Journal of separation science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Direct oral anticoagulants (DOACs), including apixaban, dabigatran, edoxaban, and rivaroxaban, may require quantitative measurement in selected clinical situations despite fixed-dose administration. This study developed and validated a quick, easy, cheap, effective, rugged, and safe (QuEChERS)-assisted liquid chromatography-tandem mass spectrometry method for their simultaneous determination in citrate plasma and quantitative dried plasma spot (qDPS) samples. Chromatographic separation was achieved on a Kinetex PS C18 column using a 4.0 min gradient, followed by positive electrospray ionization and scheduled multiple reaction monitoring. Sample preparation was optimized by comparing acetonitrile (ACN) protein precipitation, unbuffered and citrate-buffered QuEChERS extraction salts, and dispersive solid-phase extraction clean-up using primary-secondary amine, C18, EMR Lipid, Z-Sep+, or their combinations. The final procedure comprised ACN extraction with MgSO
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