A widespread actinobacterial G protein system regulates production of specialized metabolites in

Luis M Cantu Morin, Aditya Vunnum, Sydney Binns, Matthew F Traxler

Abstract read

In one paragraph

Article in mSphere, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

Update of
A widespread Actinobacterial G Protein System regulates production of specialized metabolites in2025

5 · Who and what money

Authors and funding

4 authors.

Luis M Cantu MorinDepartment of Plant and Microbial Biology, University of California Berkeley, Berkeley, California, USA.

Aditya VunnumDepartment of Plant and Microbial Biology, University of California Berkeley, Berkeley, California, USA.

Sydney BinnsDepartment of Plant and Microbial Biology, University of California Berkeley, Berkeley, California, USA.

Matthew F TraxlerDepartment of Plant and Microbial Biology, University of California Berkeley, Berkeley, California, USA.ORCID 0000-0001-8430-595X

Funding

Connecting specialized metabolism to social cues in actinomycete bacteriaR35GM128849 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Matthew F Traxler · 2018 to 2026

$3.3M

NIGMS NIH HHS R35 GM128849NIGMS NIH HHS R35GM128849

6 · The paper itself

Abstract

Actinobacterial G protein systems (AGPSs), encoded by operons called conservons, are regulatory systems that are broadly distributed within Actinomycetota. AGPSs contain a minimum of four proteins, namely, a sensor histidine kinase, a small Ras-like GTPase, a roadblock/MglB protein (likely a GTPase activating protein), and a protein that likely functions as a guanine-nucleotide exchange factor (GEF). While progress has been made in understanding AGPS function at the mechanistic level, the phylogenetic distribution of individual AGPSs and the genes and processes they regulate remain largely unmapped. Previously, the Cvn8 AGPS of

Indexed as

Bacterial ProteinsGene Expression Regulation, BacterialStreptomyces coelicolorActinobacteriaAnthraquinonesAnti-Bacterial AgentsBenzoisochromanequinonesPhylogenyProdigiosinSecondary MetabolismactinorhodinAnthraquinonesAnti-Bacterial AgentsBacterial ProteinsBenzoisochromanequinonesProdigiosinconservonmicrobial interactionsnatural productsStreptomyces

Identifiers

PMID42599104

DOI10.1128/msphere.00568-25

PMCPMC13621833

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.