Evidence map›Paper›PMID 42599071›Full record

ReviewJournal of child psychology and psychiatry, and allied disciplines2026

Annual Research Review: Beyond the target - understanding crossover effects in family-centered prevention.

Arin M Connell, Marina Epstein, Rachel McClaine, Karryn Satchell, Max Halvorson, Miguel Mariscal

Abstract readReview
In one paragraph

Review in Journal of child psychology and psychiatry, and allied disciplines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Arin M ConnellDepartment of Psychological Sciences, Case Western Reserve University, Cleveland, OH, USA.
Marina EpsteinSocial Development Research Group, School of Social Work, University of Washington, Seattle, WA, USA.
Rachel McClaineDepartment of Psychological Sciences, Case Western Reserve University, Cleveland, OH, USA.
Karryn SatchellSocial Development Research Group, School of Social Work, University of Washington, Seattle, WA, USA.
Max HalvorsonSocial Development Research Group, School of Social Work, University of Washington, Seattle, WA, USA.
Miguel MariscalSocial Development Research Group, School of Social Work, University of Washington, Seattle, WA, USA.

Funding

Collaborative to understand impacts of early preventive interventions on suicide and overdose mortality using data harmonization methodologyU01MH137067 · NIMH · JOHNS HOPKINS UNIVERSITY · PI Arin M Connell, Marina Epstein · 2024 to 2026
$7.9M
Social Determinants of Health, Family Functioning, and the Family Check-Up: Neighborhood and Educational Influences on Parenting, Youth Mental Health,and Response to Intervention.F31MH142011 · NIMH · CASE WESTERN RESERVE UNIVERSITY · PI MCCLAINE, RACHEL · 2025 to 2025
$50k
NIH HHSNIMH NIH HHS 1U01MH137067-0NIMH NIH HHS F31 MH142011NIMH NIH HHS U01 MH137067U.S. Department of Health and Human Services
6 · The paper itself

Abstract

Preventive interventions frequently find positive effects that were not the original targets of the intervention, called crossover effects. This review aimed to catalog crossover effects of family-centered prevention programs (FCPP). The authors searched prevention program registries, screened 2,556 prevention programs (including duplicates across registries), and reviewed 166 programs against inclusion criteria. Of these 24 FCPPs with crossover effects were cataloged. Seven crossover domains (internalizing, externalizing, suicidal thoughts and behaviors, physical health, academics, high-risk sexual behaviors, and parental depression) were reviewed. Fourteen of the 24 reviewed programs yielded evidence of significant main effects on at least one crossover domain, with several yielding evidence across multiple crossover domains. Understanding the full breadth and reach of preventive interventions, including crossover effects, can increase efficiency and cost-effectiveness of prevention strategies. Most programs reviewed reported more than one crossover effect, and many others are encouraged to test the data for additional benefits. New data harmonization techniques can assist with low base-rate outcomes and smaller subgroup restrictions. Finally, more mechanistic and longitudinal investigations are needed to effectively leverage the FCPPs with the most widespread crossover effects.

Indexed as

academicCrossover effectsexternalizingfamilyinternalizingphysical healthpreventionsexual risksuicide

Identifiers

PMID42599071
PMCPMC13596070

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.