ReviewJournal of Indian Society of Periodontology
Effectiveness of Vitamin C in managing gingival hyperpigmentation: A systematic review and meta-analysis.
Review in Journal of Indian Society of Periodontology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Gingival hyperpigmentation is a significant esthetic concern, particularly in individuals with high smile lines. Traditional surgical methods for depigmentation often face the challenge of recurrence. Vitamin C, due to its antioxidant properties and role in melanin inhibition, has emerged as a promising adjunctive agent for gingival depigmentation. Aim: This systematic review and meta-analysis aimed to evaluate the effectiveness of Vitamin C in managing gingival hyperpigmentation, either as a standalone treatment or in combination with other modalities. Materials and Methods: The protocol of this systematic review was registered in PROSPERO (CRD42024613787), and it was in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analysis 2020 guidelines. A comprehensive literature search was conducted across multiple databases, including PubMed, Scopus, Cochrane Library, and Google Scholar, for studies published between 2018 and 2024. The review included randomized controlled trials (RCTs) and clinical trials comparing Vitamin C interventions to conventional depigmentation techniques, and a meta-analysis was conducted using the standardised mean difference (SMD) as the effect measure. Results: Eight studies were included for qualitative synthesis and three RCTs for quantitative analysis. The meta-analysis revealed a statistically significant improvement in depigmentation scores at 1-month follow-up (SMD: 1.93; 95% confidence interval: 1.37-2.48). However, no significant differences were observed at baseline or at the 3-month follow-up, where high heterogeneity was present. Conclusion: Vitamin C demonstrates promising short-term efficacy in the treatment of gingival hyperpigmentation, especially when used as an adjunct to conventional therapy. However, variability in protocols and long-term outcomes highlights the need for further standardized trials.
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