ArticleJournal of drug delivery science and technology2022
Retention of peptide-based vesicles in murine knee joints after intra-articular injection.
Article in Journal of drug delivery science and technology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Fine structural tuning of the assembly of elastin-collagen peptide conjugates with drug loading and manipulation of molecular interactions.Biomaterials science · 2026Article
- Recent advances in extracellular matrix-inspired nanocarriers.Expert opinion on drug delivery · 2025Review
- Controlled Release of Drugs from Extracellular Matrix-Derived Peptide-Based Nanovesicles through Tailored Noncovalent Interactions.Biomacromolecules · 2024Article
- Targeting damaged collagen for intra-articular delivery of therapeutics using collagen hybridizing peptides.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
While intra-articular injections continue to be utilized in the remediation of osteoarthritis, the efficacy of such treatment regimens continues to be plagued by the rapid clearance of drug therapeutics from the joint space, independent of whether the therapeutic is a macromolecule or a small-molecule pharmaceutical. Nanoparticle drug delivery vehicles have emerged as potential candidates to enhance the retention of therapeutics within the joint, with a wide variety of formulations that utilize retention strategies such as electrostatic interactions, collagen-type II binding domains, and passive targeting based on the physical size of the particles. However, despite these advances, significant issues regarding carrier and drug retention within the joint remain, so we sought to explore a novel nanoparticle retention scheme based on the integration of collagen peptides. In this work, we demonstrate the successful synthesis and fluorophore labeling of elastin-
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.