Evidence map›Paper›PMID 42598602›Full record

ArticleOphthalmology science2026

High-Resolution OCT of Retinal Vessels in Eyes with Vascular Leakage.

Francesco Romano, Francesca Lamanna, Mariano Cozzi, Francesco Cutrupi, Pier Luigi Surico, David Sarraf, SriniVas Sadda, Vishali Gupta, Ahmed Abu El Asrar, Luca Cimino and 2 more

Abstract read
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Article in Ophthalmology science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Francesco RomanoEye Clinic, Department of Biomedical and Clinical Sciences, Ospedale Luigi Sacco, University of Milan, Milan, Italy.
Francesca LamannaEye Clinic, Department of Biomedical and Clinical Sciences, Ospedale Luigi Sacco, University of Milan, Milan, Italy.
Mariano CozziEye Clinic, Department of Biomedical and Clinical Sciences, Ospedale Luigi Sacco, University of Milan, Milan, Italy.
Francesco CutrupiDepartment of Ophthalmology, Fondazione Policlinico Campus Bio-Medico, Rome, Italy.
Pier Luigi SuricoDepartment of Sense Organs, Sapienza University of Rome, Rome, Italy.
David SarrafRetina Division, Stein Eye Institute, David Geffen School of Medicine at UCLA, University of California, Los Angeles, California.
SriniVas SaddaDoheny Eye Institute, Pasadena, California.
Vishali GuptaAdvanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Ahmed Abu El AsrarDepartment of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Luca CiminoOcular Immunology Unit, Azienda USL-IRCCS of Reggio Emilia, Reggio Emilia, Italy.
Giovanni StaurenghiEye Clinic, Department of Biomedical and Clinical Sciences, Ospedale Luigi Sacco, University of Milan, Milan, Italy.
Alessandro InvernizziEye Clinic, Department of Biomedical and Clinical Sciences, Ospedale Luigi Sacco, University of Milan, Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To identify and compare qualitative and quantitative retinal venous wall alterations associated with fluorescein angiography (FA)-documented vascular leakage in eyes with retinal vein occlusion (RVO) and active uveitis using high-resolution OCT (High-Res OCT), and to assess their longitudinal evolution after uveitis remission. Design: Prospective, observational, cross-sectional and longitudinal study. Participants: Twenty-nine eyes from 25 adults with FA-confirmed perivenular leakage due to new-onset RVO (16 eyes) or active uveitis (13 eyes). A subset of uveitis eyes underwent follow-up imaging after clinical remission. Methods: High-resolution OCT line scans were acquired longitudinally along leaking retinal veins. Qualitative features (wall splitting, outer fuzziness, hyporeflective spaces) and quantitative metrics (lumen diameter, inner and outer vessel wall thickness, and overlying inner retinal layer thickness) were assessed and compared between RVO and uveitis and against age-, sex-, and laterality-matched healthy control vessels. Longitudinal changes were analyzed in uveitis eyes after remission. Main Outcome Measures: High-resolution OCT qualitative features and quantitative measurements of retinal venous wall and perivascular structure. Results: Forty leaking retinal veins (21 RVO, 19 uveitis) were analyzed. Eyes with RVO demonstrated greater lumen diameter (median, 180 μm vs. 122 μm; Conclusions: High-resolution OCT identified different patterns of retinal venous wall involvement associated with vascular leakage in eyes with RVO and uveitis. These findings support further evaluation of High-Res OCT as an imaging modality for characterizing retinal vascular leakage and monitoring inflammatory disease activity. Financial Disclosures: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

Indexed as

High-resolution OCTRetina vein occlusionRetina vesselsVascular leakageVasculitis

Identifiers

PMID42598602
PMCPMC13472033

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