ArticleCase reports in dentistry2026
Unicentric Castleman Disease Involving the Submandibular Gland: A Case Report.
Article in Case reports in dentistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Unicentric Castleman Disease Involving the Submandibular Gland: A Case Report.Case reports in dentistry · 2026Article
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6 authors.
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Abstract
This report describes a rare case of unicentric Castleman disease (UCD) involving the submandibular gland and lymph nodes. A 56-year-old man presented with an asymptomatic, slowly growing left submandibular mass. Imaging revealed well-defined heterogeneous structures with prominent vascularity. Excisional biopsy of the gland and adjacent lymph nodes was performed. Histopathological examination showed features characteristic of the hyaline-vascular variant of Castleman disease, including atrophic germinal centers with concentric "onion-skin" layering and prominent vascularity, confirmed by immunohistochemistry. No systemic involvement was found. These findings confirmed the unicentric subtype. After complete surgical excision and 3 years of follow-up, the patient remained disease-free. This report underscores that UCD can occur in the submandibular region, should be included in the differential diagnosis of submandibular masses, diagnosed by characteristic imaging (well-defined heterogeneous structures with prominent vascularity) and histopathology (hyaline-vascular variant), and cured by complete surgical resection.
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