Evidence map›Paper›PMID 42598519›Full record

ArticleBioactive materials2027

Long-term exploratory evaluation of an acellular biomimetic polyfascicular nerve guidance conduit for peripheral nerve repair in a rhesus macaque model.

Yu-Jin Kim, In Cheul Choi, Jiyeon Cho, Goeun Choe, Seongryeol Ye, Kyung Seob Lim, Chang-Yeop Jeon, Jinyoung Won, Hyeon-Gu Yeo, Keonwoo Kim and 5 more

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Article in Bioactive materials, 2027. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yu-Jin KimBiomaterials Research Center, Korea Institute of Science and Technology, Seoul, 02792, Republic of Korea.
In Cheul ChoiDepartment of Orthopedic Surgery, College of Medicine, Korea University, Seoul, 02841, Republic of Korea.
Jiyeon ChoNational Primate Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, 28116, Republic of Korea.
Goeun ChoeBiomaterials Research Center, Korea Institute of Science and Technology, Seoul, 02792, Republic of Korea.
Seongryeol YeBiomaterials Research Center, Korea Institute of Science and Technology, Seoul, 02792, Republic of Korea.
Kyung Seob LimFuturistic Animal Resource & Research Center, KRIBB, Cheongju, 28116, Republic of Korea.
Chang-Yeop JeonNational Primate Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, 28116, Republic of Korea.
Jinyoung WonNational Primate Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, 28116, Republic of Korea.
Hyeon-Gu YeoNational Primate Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, 28116, Republic of Korea.
Keonwoo KimNational Primate Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, 28116, Republic of Korea.
Jin YooBiomaterials Research Center, Korea Institute of Science and Technology, Seoul, 02792, Republic of Korea.
Jae Jun NamDepartment of Orthopedic Surgery, College of Medicine, Korea University, Seoul, 02841, Republic of Korea.
Youngjeon LeeNational Primate Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, 28116, Republic of Korea.
Jong Woong ParkDepartment of Orthopedic Surgery, College of Medicine, Korea University, Seoul, 02841, Republic of Korea.
Youngmee JungBiomaterials Research Center, Korea Institute of Science and Technology, Seoul, 02792, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peripheral nerve injury (PNI) affects millions worldwide, yet currently approved nerve guidance conduits (NGCs) have limited ability to recapitulate the native fascicular architecture that supports organized axonal regeneration. Here, we present an acellular biomimetic multi-fascicle NGC (MFNGC) constructed by integrating electrospun poly(L-lactide-co-ε-caprolactone) (PLCL) membranes with visible-light-crosslinked gelatin hydrogel guide structures, without cells or exogenous growth factors. The MFNGC incorporates three inner conduits mimicking perineurial fascicles enclosed within an epineurium-like outer conduit, approximating key architectural features of the native median nerve in rhesus macaques. In a 12-month exploratory follow-up study using a 15-mm median nerve defect model in three rhesus macaques (

Indexed as

Multi-fascicle conduitNerve guidance conduitPeripheral nerve injuryPeripheral nerve regenerationRhesus macaque model

Identifiers

PMID42598519
PMCPMC13471289

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.