Evidence map›Paper›PMID 42598488›Full record

ArticleAnnals of cardiothoracic surgery2026

The aortic window: a temporal framework for acute type A aortic dissection.

Farhin Holia, Aung Ye Oo, Colin D Bicknell, Thanos Athanasiou, Catherine Fowler, Christoph A Nienaber, Graham Cooper, Eva Göncz, John A Elefteriades, Hans-Joachim Schäfers

Abstract read
In one paragraph

Article in Annals of cardiothoracic surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Farhin HoliaDepartment of Cardiothoracic Surgery, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.ORCID https://orcid.org/0009-0004-5413-0799
Aung Ye OoDepartment of Cardiothoracic Surgery, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.ORCID https://orcid.org/0000-0003-2614-040X
Colin D BicknellImperial Vascular Unit, Imperial College Healthcare NHS Trust and Imperial College London, London, UK.
Thanos AthanasiouDepartment of Surgery and Cancer, Imperial College London, London, UK.
Catherine FowlerThe Aortic Dissection Charitable Trust, Chesterfield, UK.
Christoph A NienaberDivision of Cardiology and Aortic Centre, Royal Brompton and Harefield Hospitals, Guy's and St Thomas' NHS Foundation Trust, London, UK.
Graham CooperThe Aortic Dissection Charitable Trust, Chesterfield, UK.
Eva GönczCharité, Universitätsmedizin Berlin, Berlin, Germany.
John A ElefteriadesYale University School of Medicine, Section of Cardiac Surgery, New Haven, CT, USA.ORCID https://orcid.org/0000-0001-6255-8139
Hans-Joachim SchäfersDepartment of Cardiac and Thoracic Surgery, Saarland University Medical Centre, Homburg/Saar, Germany.ORCID https://orcid.org/0000-0002-1120-5453

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Acute type A aortic dissection (ATAAD) is a surgical emergency with time-dependent mortality. Surgical outcomes in high-volume centers are excellent, yet population-level outcomes remain catastrophic. This gap reflects a systems failure in recognition, diagnosis, and coordination rather than surgical inadequacy, and no formal time-based pathway currently governs care from emergency presentation to surgery. Methods: Current epidemiology, international guidelines, registry evidence, and national audit data were synthesized, together with the structure of established time-critical pathways in ST-elevation myocardial infarction, stroke, major trauma, and sepsis, and multidisciplinary and patient-and-public input, to derive a temporal framework for ATAAD. The framework is advanced as a hypothesis for formal international consensus validation rather than an empirically validated standard. Results: The proposed framework, the aortic window, is a phased pathway from emergency-department (ED) arrival to first surgical incision, structured as RACE (four acute phases: REACH, ALERT, CONVEY, ESCALATE) and RESTORE (recovery and lifelong surveillance), and operationalized through a named activation protocol. ED-to-incision time is the principal whole-system endpoint, chosen because it captures pre-diagnosis delay that diagnosis-anchored metrics exclude. Process and outcome measures are defined at case level with scheduled network review, aligned to established national audit registries. Implementation is staged and incorporates an education and run-in period before performance assessment. Conclusions: The aortic window reframes ATAAD as a system-level, time-critical emergency amenable to the organizational solutions that improved outcomes in other time-dependent conditions. The proposed targets require prospective evaluation but provide a structured, measurable basis for coordinated pathway improvement.

Indexed as

Acute type A aortic dissection (ATAAD)clinical auditquality improvementregionalizationtime-critical pathway

Identifiers

PMID42598488
PMCPMC13471113

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.