Evidence map›Paper›PMID 42598363›Full record

ArticleACS omega2026

Human Insulin Enhances Avobenzone Photostability while Retaining Its Biological Activity.

Deepak Kumar Sahoo, Sachin Mallikarjun More, Pooja Dhurjad, Chandana Kumbharagatte Prakash, Abrar Hussain Qadri, Yavvari Sravani, Srinivasarao Raghothama, Prasanna D Revanasiddappa, Rajesh Sonti, Anil Kumar Pasupulati and 1 more

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Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Deepak Kumar SahooDepartment of Chemistry, School of Chemical Sciences, Central University of Karnataka, Kalaburagi, Karnataka 585367, India.ORCID https://orcid.org/0009-0000-9111-609X
Sachin Mallikarjun MoreDepartment of Chemistry, School of Chemical Sciences, Central University of Karnataka, Kalaburagi, Karnataka 585367, India.
Pooja DhurjadDepartment of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, Telangana 500037, India.
Chandana Kumbharagatte PrakashDepartment of Biotechnology, Siddaganga Institute of Technology, Tumkur, Karnataka 572103, India.
Abrar Hussain QadriDepartment of Biochemistry, University of Hyderabad, Hyderabad, Telangana 500046, India.
Yavvari SravaniDepartment of Chemistry, School of Chemical Sciences, Central University of Karnataka, Kalaburagi, Karnataka 585367, India.
Srinivasarao RaghothamaDepartment of Chemistry, School of Chemical Sciences, Central University of Karnataka, Kalaburagi, Karnataka 585367, India.
Prasanna D RevanasiddappaDepartment of Biotechnology, Siddaganga Institute of Technology, Tumkur, Karnataka 572103, India.
Rajesh SontiDepartment of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, Telangana 500037, India.ORCID https://orcid.org/0000-0001-7631-5605
Anil Kumar PasupulatiDepartment of Biochemistry, University of Hyderabad, Hyderabad, Telangana 500046, India.
Konkallu Hanumae GowdDepartment of Chemistry, School of Chemical Sciences, Central University of Karnataka, Kalaburagi, Karnataka 585367, India.ORCID https://orcid.org/0000-0002-8991-9368

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human insulin was selected as a model polypeptide to investigate avobenzone photoprotection because of its structural stability, dermatological relevance, and role in diabetes therapy. Avobenzone, a widely used chemical ultraviolet A (UVA) filter, undergoes photodegradation upon UV exposure, limiting its long-term efficacy in sunscreen formulations. This study systematically examined the interaction between insulin and avobenzone to evaluate its effects on photostability, binding behavior, and insulin bioactivity. The UV spectroscopy-based photodegradation studies demonstrated that insulin significantly enhances avobenzone photostability under both sunlight and UV irradiation. The interaction was characterized using ESI-MS/MS, fluorescence spectroscopy,

Identifiers

PMID42598363
PMCPMC13470807

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.