ArticleJournal of Indian Society of Periodontology
Estimation and comparison of salivary matrix metalloproteinase-9 and S100A8 levels in reverse smokers, smokers, and non-smokers with periodontitis.
Article in Journal of Indian Society of Periodontology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Diagnosing periodontitis using traditional methods can reflect past tissue destruction and not indicate the active disease. This highlights the need for accurate and specific diagnostic methods that assess the current disease activity more accurately. Thus, the present study aimed to evaluate the diagnostic performance and association of salivary matrix metalloproteinase-9 (MMP-9) and S100A8 levels with periodontitis among reverse smokers, smokers, and nonsmokers. Materials and Methods: Thirteen milliliters of saliva sample were collected from 100 participants, 25 each of reverse smokers with periodontitis (RS + P), smokers with periodontitis (S + P), nonsmokers with periodontitis (NS + P) and systemically and periodontally healthy individuals (HI). Probing pocket depth and clinical attachment loss were measured and correlated with the levels of MMP-9 and S100A8, which were tested by the Enzyme-linked immunosorbent assay method. Results: The levels of both biomarkers were significantly higher ( Conclusions: Within limitations, salivary MMP-9 and S100A8 may be possible biomarkers for smokers (especially reverse smokers) with periodontitis and have a good screening potential for periodontitis. However, more studies are essential to understand the prognostic value of salivary MMP-9 and S100A8 for periodontitis.
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