Evidence map›Paper›PMID 42598281›Full record

ArticleNeurobiology of stress2026

Loss of pleasure (Anhedonia): A sex-dependent, cross-species consequence of unpredictable signals to the perinatal brain.

Anna M Zhou, Madison R Tetzlaff, Laura M Glynn, Curt A Sandman, Hal S Stern, Tallie Z Baram, Elysia Poggi Davis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of stress, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Anna M ZhouDepartment of Psychiatry, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
Madison R TetzlaffDepartment of Anatomy and Neurobiology, University of California-Irvine, Irvine, CA, 92697, USA.
Laura M GlynnDepartment of Psychology, Chapman University, Orange, CA, 92866, USA.
Curt A SandmanDepartment of Psychiatry and Human Behavior, University of California-Irvine, CA, 92697, USA.
Hal S SternDepartment of Statistics, University of California-Irvine, Irvine, CA, 92697, USA.
Tallie Z BaramDepartment of Anatomy and Neurobiology, University of California-Irvine, Irvine, CA, 92697, USA.
Elysia Poggi DavisDepartment of Psychology, University of Denver, Denver, CO, 80208, USA.

Funding

Structural & Network-Function Correlates of Fragmented Early-Life Across SpeciesP50MH096889 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI SANDMAN, CURT ALAN · 2013 to 2023
$25.4M
Development of Psychopathology, Psychobiology, & BehaviorT32MH015442 · NIMH · UNIVERSITY OF COLORADO DENVER · PI JASON R TREGELLAS · 1985 to 2026
$10.2M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM008620 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI GOLDIN, ALAN L · 1999 to 2023
$8.1M
Maternal Stress and Fetal/Infant DevelopmentR01NS041298 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI SANDMAN, CURT ALAN · 2002 to 2006
$2.8M
Fetal Programming of Early DevelopmentR01HD051852 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI SANDMAN, CURT ALAN · 2006 to 2010
$2.7M
Pregnancy Influences Environmental SensitivityR01HD040967 · NICHD · UNIVERSITY OF CALIFORNIA IRVINE · PI GLYNN, LAURA M · 2001 to 2005
$1.7M
STRESS AND BIRTH OUTCOMESR01HD028413 · NICHD · UNIVERSITY OF CALIFORNIA IRVINE · PI SANDMAN, CURT ALAN · 1992 to 2001
$659k
NICHD NIH HHS R01 HD028413NICHD NIH HHS R01 HD040967NICHD NIH HHS R01 HD051852NIGMS NIH HHS T32 GM008620NIMH NIH HHS P50 MH096889NIMH NIH HHS T32 MH015442NINDS NIH HHS R01 NS041298
6 · The paper itself

Abstract

Reward seeking is an essential component of human behavior. Anhedonia (reduced motivation for and pleasure in reward) is a core feature of several mental illnesses. Early life adversity associates with later impairments in reward behaviors and related psychopathology; however, specific aspects of early adversity that lead to disrupted reward behaviors are unknown. Capitalizing on evidence that unpredictable signals to the developing brain constitute adversity and influence neurodevelopment, we examined whether exposure to perinatal unpredictable maternal signals associated with diminished reward responsivity, and probed causality using experiments in mice. We analyzed a longitudinal human study

Indexed as

AdversityCross-speciesDepressionEarly experienceMaternal careReward

Identifiers

PMID42598281
PMCPMC13470535

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.