ArticleVaccine: X2025
Mincle receptor agonist UM-1098 and TLR4 agonist INI-2002 combination adjuvant enhances Th1 responses and provides protection against
Article in Vaccine: X, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Adjuvants targeting pattern recognition receptors (PRRs) can selectively skew the immune responses towards a Th1, Th2 or Th17 phenotype following vaccination. However, for diseases such as tuberculosis (TB), mixed Th cell responses, especially Th1/Th17 are considered important for protection. Hence, the potential of combining adjuvants to achieve mixed and synergistic immune responses warrants further investigation. Herein, we evaluated the combination of a Mincle and a Toll-like receptor (TLR) 4 agonist for its capacity to induce greater and more protective Th1/Th17 responses than use of either adjuvant individually. Stimulation of human PBMCs with the synthetic UM-1098/INI-2002 adjuvant combination led to synergistic IL-1β and TNF-α production. Importantly, vaccination of mice with the
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