ArticleFood chemistry: X2026
High-pressure-modified silkworm pupae protein attenuates autophagy-related alterations associated with immune tolerance.
Article in Food chemistry: X, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Silkworm pupae protein (SPP) is a sustainable protein source, but its application is limited by allergenicity and insufficient immune tolerance. This study investigated the immunological mechanisms underlying the reduced allergenicity of SPP following high pressure processing (HPP), with a focus on dendritic cell (DC) autophagy. In a murine food allergy model, SPP sensitization significantly upregulated autophagy-related genes (Atg5, Atg7, and Becn1) and increased ATG5 and LC3-II protein expression while reducing p62 levels in DCs. Functionally, HPP-SPP promoted regulatory T cell (Treg) expansion
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