Evidence map›Paper›PMID 42598205›Full record

ArticleMaterials today. Bio2026

Photothermal immunomodulatory nanoagents synchronize immunogenic cell death and TAM reprogramming for colorectal cancer immunotherapy.

Xiaodan Chen, Junrong Zhang, Jing Qin, Dechun Zheng, Hui Zheng, Mengxin Wang, Zhengyu Hu, Hailong Lin, Jingchao Li, Lin Lin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiaodan ChenDepartment of Radiology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, 350014, China.
Junrong ZhangDepartment of General Surgery (Emergency Surgery), Fujian Medical University Union Hospital, Fujian, 350001, China.
Jing QinDepartment of Radiology, Fujian Medical University Union Hospital, Fuzhou, 350001, China.
Dechun ZhengDepartment of Radiology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, 350014, China.
Hui ZhengDepartment of Radiology, Fujian Medical University Union Hospital, Fuzhou, 350001, China.
Mengxin WangState Key Laboratory of Advanced Fiber Materials, College of Biological Science and Medical Engineering, Donghua University, Shanghai, 201620, China.
Zhengyu HuState Key Laboratory of Advanced Fiber Materials, College of Biological Science and Medical Engineering, Donghua University, Shanghai, 201620, China.
Hailong LinDepartment of Radiology, Fujian Medical University Union Hospital, Fuzhou, 350001, China.
Jingchao LiState Key Laboratory of Advanced Fiber Materials, College of Biological Science and Medical Engineering, Donghua University, Shanghai, 201620, China.
Lin LinDepartment of Radiology, Fujian Medical University Union Hospital, Fuzhou, 350001, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The immunosuppressive tumor microenvironment (TME) continues a critical obstacle to effective colorectal cancer immunotherapy. A photothermal immunomodulatory nanoagent was developed to sequentially ignite immunogenic cell death (ICD) and reprogram tumor-associated macrophage (TAM) through stimuli-responsive cascade actions, thereby enhancing antitumor effect. The hybrid nanoagent (MIB@HA) containing hollow manganese dioxide (H-MnO

Indexed as

Colorectal cancerImmunomodulatory nanoparticlesImmunotherapyNitric oxideTumor-associated macrophages

Identifiers

PMID42598205
PMCPMC13470504

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.