Evidence map›Paper›PMID 42598192›Full record

ArticleNeurophotonics2026

Cedalion tutorial: a Python-based framework for comprehensive analysis of multimodal fNIRS and DOT from the lab to the everyday world.

Eike Middell, Laura B Carlton, Shakiba Moradi, Tomás Codina, Thomas Fischer, Josef Cutler, Shannon M Kelley, Jacqueline Behrendt, Theekshana Dissanayake, Nils Harmening and 3 more

Abstract read
In one paragraph

Article in Neurophotonics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Eike MiddellTechnische Universität Berlin, Intelligent Biomedical Sensing (IBS) Lab, Berlin, Germany.ORCID https://orcid.org/0009-0002-1930-7646
Laura B CarltonBoston University, Neurophotonics Center, Biomedical Engineering, Boston, Massachusetts, United States.
Shakiba MoradiTechnische Universität Berlin, Intelligent Biomedical Sensing (IBS) Lab, Berlin, Germany.
Tomás CodinaTechnische Universität Berlin, Intelligent Biomedical Sensing (IBS) Lab, Berlin, Germany.
Thomas FischerTechnische Universität Berlin, Intelligent Biomedical Sensing (IBS) Lab, Berlin, Germany.
Josef CutlerTechnische Universität Berlin, Intelligent Biomedical Sensing (IBS) Lab, Berlin, Germany.ORCID https://orcid.org/0009-0003-0155-3205
Shannon M KelleyBoston University, Neurophotonics Center, Biomedical Engineering, Boston, Massachusetts, United States.
Jacqueline BehrendtTechnische Universität Berlin, Intelligent Biomedical Sensing (IBS) Lab, Berlin, Germany.ORCID https://orcid.org/0009-0003-1793-4520
Theekshana DissanayakeTechnische Universität Berlin, Intelligent Biomedical Sensing (IBS) Lab, Berlin, Germany.
Nils HarmeningTechnische Universität Berlin, Intelligent Biomedical Sensing (IBS) Lab, Berlin, Germany.ORCID https://orcid.org/0000-0002-4150-1915
Meryem A YücelBoston University, Neurophotonics Center, Biomedical Engineering, Boston, Massachusetts, United States.ORCID https://orcid.org/0000-0002-4291-2847
David A BoasBoston University, Neurophotonics Center, Biomedical Engineering, Boston, Massachusetts, United States.ORCID https://orcid.org/0000-0002-6709-7711
Alexander von LühmannTechnische Universität Berlin, Intelligent Biomedical Sensing (IBS) Lab, Berlin, Germany.ORCID https://orcid.org/0000-0002-4995-293X

Funding

The Neuroscience of Everyday World- A novel wearable system for continuous measurement of brain functionU01EB029856 · NIBIB · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI BOAS, DAVID A, KIRAN, SWATHI · 2020 to 2024
$6.5M
A transformative method for functional brain imaging with Speckle Contrast Optical SpectroscopyUG3EB034710 · NIBIB · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI BOAS, DAVID A, CHENG, XIAOJUN · 2023 to 2025
$1.1M
NIBIB NIH HHS U01 EB029856NIBIB NIH HHS UG3 EB034710
6 · The paper itself

Abstract

Functional near-infrared spectroscopy (fNIRS) and diffuse optical 1 tomography (DOT) are rapidly evolving toward wearable, multimodal, data-driven, and artificial-intelligence-supported neuroimaging in the everyday world. However, current analytical tools are fragmented across platforms, limiting reproducibility, interoperability, and integration with modern machine learning (ML) workflows. Cedalion is a Python-based open-source framework designed to unify advanced model-based and data-driven analysis of multimodal fNIRS and DOT data within a reproducible, extensible, and community-driven environment. Cedalion integrates forward modeling, photogrammetric optode coregistration, signal processing, general linear model (GLM) analysis, DOT image reconstruction, and ML-based data-driven methods within a single standardized architecture based on the Python ecosystem. It adheres to SNIRF and BIDS standards, supports cloud-executable Jupyter notebooks, and provides containerized workflows for scalable, fully reproducible analysis pipelines that can be provided alongside original research publications. Cedalion connects established optical-neuroimaging pipelines with ML frameworks such as scikit-learn and PyTorch, enabling seamless multimodal fusion with electroencephalography (EEG), magnetoencephalography (MEG), and physiological data. It implements validated algorithms for signal quality assessment, motion correction, GLM modeling, and DOT reconstruction, complemented by modules for simulation, data augmentation, and multimodal physiology analysis. Automated documentation links each method to its source publication, and continuous-integration testing ensures robustness. This tutorial paper provides seven fully executable notebooks that demonstrate core features. Cedalion offers an open, transparent, and community-extensible foundation that supports reproducible, scalable, and cloud- and ML-ready fNIRS/ DOT workflows for laboratory-based and real-world neuroimaging.

Indexed as

data-drivendiffuse optical tomographyeveryday neuroscience.functional near-infrared spectroscopymachine learningmultimodalphysiology

Identifiers

PMID42598192
PMCPMC13471981

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.