ArticleBioactive materials2027
Biomimetic stress granules replenish lysosomal repair to reinstate macrophage immunometabolic antibacterial programs.
Article in Bioactive materials, 2027. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Severe intracellular bacterial infection can progressively compromise lysosomal defence in macrophages, yet the underlying repair bottleneck remains unclear. Here we identify a time-dependent exhaustion of stress granule (SG)-associated lysosomal repair during sustained infection: progressive depletion of core SG components, including G3BP1 and galectin-3 (Gal-3), undermines lysosomal membrane resealing, resulting in lysosomal deacidification and persistent cytosolic acidification. This pH imbalance suppresses glycolytic metabolism and blunts macrophage pro-inflammatory antibacterial programs, thereby enabling intracellular bacterial persistence. Since this exhausted repair module cannot be readily reconstituted by conventional pharmacological or genetic approaches, we engineer biomimetic stress granules (BSGs), Gal-3-functionalized nanodiscs cloaked in acid-responsive fusogen-expressing macrophage membrane vesicles (Gal3-NDs@EF-MNVs), to achieve sequential targeting and cytosolic delivery to damaged lysosomes. BSGs stabilize membrane lesions, suppress lysosomal leakage and restore lysosomal acidification, pH homeostasis and metabolic fitness, thereby recapitulating the 'plugging' behavior of native stress granules at sites of membrane injury. This work establishes biomimetic organelle repair as a general, materials-driven paradigm to restore innate immunity against intracellular infections - without escalating antibiotics or genetic manipulation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.