Evidence map›Paper›PMID 42597969›Full record

ArticleFrontiers in immunology2026

Unveiling the clinical and proteomic spectrum of relapsing polychondritis with respiratory involvement.

Xia Fang, Ximing Liao, Wei Gao, Wei Pei, Wujian Xu, Yuanyuan Wang, Yin Wu, Rongzhang Chen, Jiajun Ding, Muyun Wang and 5 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Xia Fang *Department of Respiratory and Critical Care Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Ximing Liao *Department of Respiratory and Critical Care Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Wei Gao *Department of Respiratory and Critical Care Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Wei PeiDepartment of Respiratory and Critical Care Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Wujian XuDepartment of Respiratory and Critical Care Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Yuanyuan WangDepartment of Respiratory and Critical Care Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Yin WuDepartment of Respiratory and Critical Care Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Rongzhang ChenDepartment of Respiratory and Critical Care Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Jiajun DingDepartment of Respiratory and Critical Care Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Muyun WangDepartment of Respiratory and Critical Care Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Xingyan ZhuDepartment of Respiratory and Critical Care Medicine, Yingtan Hospital of Traditional Chinese Medicine, Yingtan, China.
Heng ZhangDepartment of Respiratory and Critical Care Medicine, Yancheng Hospital of Traditional Chinese Medicine, Nanjing University of Chinese Medicine, Yancheng, China.
Dan-Ni RenAcademy of Integrative Medicine, College of Integrative Medicine, Fujian Key Laboratory of Integrative Medicine on Geriatric, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
Qiang LiDepartment of Respiratory and Critical Care Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Shaoyong GaoDepartment of Respiratory and Critical Care Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Relapsing polychondritis (RP) is a rare autoimmune disease characterized by recurrent inflammation and progressive damage to cartilage. Respiratory involvement, which has a relatively high misdiagnosis rate, is the leading cause of death in RP patients, and its underlying pathogenesis remains largely unknown. Methods: Seventy-seven RP patients with respiratory involvement were enrolled in this study. The clinical characteristics, including imaging features, bronchoscopic findings, and treatment, were systematically analyzed. Latent class analysis (LCA) was used to classify patients at first hospitalization according to their bronchoscopic findings, and the relevant clinical parameters were evaluated. A proteomic technique was applied to detect proteins in the peripheral serum of healthy controls (HCs) and 35 patients. The differentially expressed proteins between these two groups were analyzed and verified by Western blot. Results: Patients with initial respiratory involvement were less likely to have ear chondritis (14.29% vs 42.86%, Conclusions: Clinical manifestations of respiratory-involved RP are nonspecific, and recognition of imaging and bronchoscopic features can facilitate the diagnosis. Patient stratification based on the patterns of airway involvement can help guide airway management strategies. Additionally, abnormalities of the complement system and NETs may play a role in its pathogenesis.

Indexed as

Polychondritis, RelapsingProteomeProteomicsAdultBiomarkersExtracellular TrapsFemaleHumansMaleMiddle AgedBiomarkersProteomecharacteristicscomplement systemneutrophil extracellular trap formationproteomicsrelapsing polychondritisrespiratory involvement

Identifiers

PMID42597969
PMCPMC13469874

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.