ArticleOncology letters2026
Role of lipid-associated fibroblasts and their signature genes FABP4, CD36 and ABCA8 in gastric cancer progression.
Article in Oncology letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Cancer-associated fibroblasts (CAFs) serve key roles in gastric cancer progression, however, the role of specific CAF subsets, particularly lipid-rich CAFs (lipo-CAFs), remains unclear. Therefore, the present study aimed to investigate whether lipo-CAFs are associated with gastric cancer progression. A total of 28 lipo-CAF-associated genes was used to classify patients with gastric cancer in The Cancer Genome Atlas Stomach Adenocarcinoma dataset. Differential expression analysis was subsequently performed to identify biological processes and pathways associated with the lipo-CAF phenotype. Validation analyses were conducted using the GSE84437 dataset and expression and survival analyses of the signature genes were performed using data from the Human Protein Atlas database and Tumor-Immune System Interaction Database. Finally, NIH-3T3 cells were transduced with lentiviral vectors to knock down the candidate genes and were co-cultured with mouse gastric cancer MFC cells to evaluate the fibroblast-mediated effects of these genes on gastric cancer cell behavior
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