HCAR1-mediated lactate signaling modulates motor behavior and regulates spontaneous firing in Purkinje cells.

Francesca Binda, Lara Buscemi, Nicolas Gurtner, Lorenz Hirt, Jean-Yves Chatton

Abstract read

In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Francesca BindaDepartment of Fundamental Neurosciences, University of Lausanne, 1005 Lausanne, Switzerland.

Lara BuscemiDepartment of Fundamental Neurosciences, University of Lausanne, 1005 Lausanne, Switzerland.

Nicolas GurtnerDepartment of Fundamental Neurosciences, University of Lausanne, 1005 Lausanne, Switzerland.

Lorenz HirtDepartment of Fundamental Neurosciences, University of Lausanne, 1005 Lausanne, Switzerland.

Jean-Yves ChattonDepartment of Fundamental Neurosciences, University of Lausanne, 1005 Lausanne, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lactate modulates several phenomena ranging from gene transcription to plasticity. Through its specific GPCR receptor HCAR1, lactate acts as a signaling molecule modulating neuronal excitability. Silencing lactate signaling promotes anxiety-like behavior and worsens epileptic seizures, highlighting the central role of HCAR1 in brain function. HCAR1 expression in the cerebellum supports the role of the receptor in motor coordination. Early experimental evidence suggesting HCAR1 expression in cerebellar Purkinje cells (PCs) together with its ability to modulate neuronal excitability qualifies the receptor as a possible modulator of PC activity with important implications for cerebellar-mediated diseases. This hypothesis was investigated using behavioral analysis and

Indexed as

cerebellumgliaHCAR1HCNhydroxycarboxylic acid receptor 1lactatemotor learningPurkinje cellsspontaneous firing

Identifiers

PMID42597666

DOI10.1016/j.isci.2026.116930

PMCPMC13470098

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.