ArticleFrontiers in oncology2026
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
10 authors.
Funding
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Abstract
Introduction: Within an integrative medicine approach that links veterinary and human health, red algae extracts are gaining attention as promising sources of natural bioactive compounds with potential anticancer properties. This study investigates the selectivity of Methods: Initial cytotoxicity was assessed in C2 canine mastocytoma cells using three assays: Alamar Blue (AB), Neutral Red Uptake (NRU), and Sulforhodamine B (SRB). Selectivity was then investigated using the AB assay in two canine cancer cell lines, C2 and CLBL-1, and two non-cancer canine cell lines, Cf2Th and MDCK. Following the selectivity assessment, the transcriptional responses induced by PCE in C2 cells were investigated by RNA sequencing (RNA-seq) and validated by quantitative PCR (qPCR). Results: PCE exhibited cytotoxic activity in C2 cells, with IC Conclusion: PCE exhibited selective cytotoxic activity toward canine cancer cell lines and induced broad transcriptional alterations in C2 mastocytoma cells. These findings support further investigation of red algae as potential anticancer candidates.
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