ArticleFrontiers in immunology2026
Adsorption-mediated modulation of lipopolysaccharide bioactivity by clinoptilolite zeolite with
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Endotoxin-driven intestinal inflammation represents a major contributor to impaired barrier function, metabolic inefficiency, and immune dysregulation in both human and animal health. Strategies that reduce luminal inflammatory triggers rather than directly suppress host signaling pathways represent an emerging paradigm in functional nutrition. Clinoptilolite zeolite, a naturally occurring aluminosilicate mineral with high adsorption capacity, is widely used as a feed additive; however, its capacity to modulate endotoxin-mediated inflammatory signaling has not been mechanistically defined. Methods: We systematically evaluated the immunomodulatory potential of feed-grade clinoptilolite Results: Clinoptilolite significantly attenuated LPS-induced NF-κB activation and nitric oxide production in innate immune cells without intrinsic pro-inflammatory activity. Pre-incubation experiments demonstrated a marked reduction in residual LPS bioactivity, supporting an adsorption-mediated mechanism. In intestinal epithelial cells, clinoptilolite selectively reduced LPS-induced IL-6 and IL-8 secretion while preserving IL-1β and TNF-α responses, indicating pathway-specific modulation rather than global immune suppression. Subchronic oral administration produced no clinically relevant hematological alterations or treatment-related histopathological changes in major organs. Conclusion: These findings provide integrated mechanistic and safety evidence that clinoptilolite zeolite attenuates endotoxin-driven inflammatory signaling by reducing luminal bioavailability while maintaining systemic tolerability. The data support its development as a functional nutritional material aimed at modulating intestinal inflammatory responses without directly targeting host intracellular pathways.
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