Evidence map›Paper›PMID 42597559›Full record

ArticleClinicoEconomics and outcomes research : CEOR2026

Cost-Effectiveness of Fetal Fibronectin Testing in Women at Risk for Preterm Birth: A Retrospective Cohort Study.

Dina Abushanab, Nader Al-Dewik, Reem AlNasr, Reem Alenany, Lana Kattan, Ghaith Alali, Alaa Al-Naama, Moza Al-Hail, Thomas Farrell, Haseebur Rahman Khan Mohammed and 4 more

Abstract read
In one paragraph

Article in ClinicoEconomics and outcomes research : CEOR, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Dina AbushanabOffice of Vice President for Health and Medical Sciences, QU Health, Qatar University, Doha, Qatar.ORCID 0000-0002-4162-8617
Nader Al-DewikDepartment of Research, Women's Wellness and Research Center, Hamad Medical Corporation, Doha, Qatar.ORCID 0000-0001-5739-1135
Reem AlNasrDepartment of Research, Women's Wellness and Research Center, Hamad Medical Corporation, Doha, Qatar.
Reem AlenanyCollege of Pharmacy, QU Health, Qatar University, Doha, Qatar.
Lana KattanCollege of Pharmacy, QU Health, Qatar University, Doha, Qatar.ORCID 0000-0002-7859-8490
Ghaith AlaliCollege of Pharmacy, QU Health, Qatar University, Doha, Qatar.ORCID 0000-0002-6889-8668
Alaa Al-NaamaObstetrics and Gynecology Department, Women's Wellness and Research Center, Hamad Medical Corporation, Doha, Qatar.
Moza Al-HailPharmacy Department, Hamad Medical Corporation, Doha, Qatar.
Thomas FarrellObstetrics and Gynecology Department, Women's Wellness and Research Center, Hamad Medical Corporation, Doha, Qatar.
Haseebur Rahman Khan MohammedPharmacy Department, Hamad Medical Corporation, Doha, Qatar.
Wessam ElkassemPharmacy Department, Hamad Medical Corporation, Doha, Qatar.
Abdulrouf PallivalapilaClinical Trial Unit, Hamad Medical Corporation, Doha, Qatar.
Binny ThomasPharmacy Department, Hamad Medical Corporation, Doha, Qatar.
Daoud Al-BadriyehCollege of Pharmacy, QU Health, Qatar University, Doha, Qatar.ORCID 0000-0001-7791-954X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The fetal fibronectin (fFN) test is used to predict true preterm delivery. This study aims to evaluate the cost-effectiveness of fFN testing versus no-fFN testing in identifying true preterm labor among women with preterm labor symptoms at risk for premature birth. Methods: This retrospective cohort-based study was conducted among women who presented with symptoms of preterm labor between 24 and 34 weeks of gestation at a tertiary care hospital in Qatar and compared outcomes between those who received fetal fibronectin (fFN) testing and those who did not. A decision-tree model compared fFN testing to no testing, with the primary outcome being the incremental cost-effectiveness ratio, representing the additional cost for a successful delivery within 48 hours of admission. Clinical data were collected from HMC medical records, and direct medical costs was locally obtained, reflecting the Qatari hospital perspective. Sensitivity analyses confirmed the study results. Results: A total of 519 women were analyzed. Significant baseline differences were observed between groups. The proportion of delivery within 48 hours was higher in the fFN group (94% vs 80%, P<0.0001). fFN testing was associated with a cost saving of QAR6,470 (US$1,777) per successful delivery. Conclusion: fFN testing was associated with better short-term clinical outcomes and lower healthcare costs. Nonetheless, due to the retrospective observational nature of the study and differences in baseline characteristics between groups, these results should be interpreted cautiously.

Indexed as

cost-effectiveness analysisfetal fibronectinpregnancypreterm birthpreterm delivery

Identifiers

PMID42597559
PMCPMC13468297

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.