Association of bone metabolic markers, bone mineral density and clinical characteristics with the occurrence of secondary fractures after PVP/PKP for osteoporotic thoracolumbar fractures: a study on logistic.

Jiawei Fu, Guanhua Xu, Jiajia Chen, Zhiming Cui

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Article in Frontiers in surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 authors.

Jiawei FuDepartment of Spine, Affiliated Nantong Clinical College of Nantong University, Nantong First People's Hospital, School of Medicine, Nantong University, Nantong, Jiangsu, China.

Guanhua XuDepartment of Spine, Affiliated Nantong Clinical College of Nantong University, Nantong First People's Hospital, School of Medicine, Nantong University, Nantong, Jiangsu, China.

Jiajia ChenDepartment of Spine, Affiliated Nantong Clinical College of Nantong University, Nantong First People's Hospital, School of Medicine, Nantong University, Nantong, Jiangsu, China.

Zhiming CuiDepartment of Spine, Affiliated Nantong Clinical College of Nantong University, Nantong First People's Hospital, School of Medicine, Nantong University, Nantong, Jiangsu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To investigate the relationship between bone metabolism markers, bone mineral density (BMD), clinical characteristics, and the occurrence of secondary fractures after percutaneous vertebroplasty (PVP) or percutaneous kyphoplasty (PKP) in patients with osteoporotic thoracolumbar fractures (OTF). Methods: A retrospective study was conducted on 107 OTF patients treated in our hospital from May 2023 to May 2024. Patients were divided into secondary fracture and non-fracture groups. Standard univariate analysis, Pearson correlation, collinearity diagnostics, and multivariate logistic regression were performed to identify independent risk factors. A predictive nomogram was constructed and internally validated via bootstrap resampling. Results: Significant differences were observed between the fracture and non-fracture groups regarding age, number of operated vertebrae, incidence of cement leakage, levels of type I collagen amino-terminal propeptide (PINP), levels of 25-hydroxyvitamin D (25(OH)D), and BMD (all Conclusion: Age, number of operated vertebrae, cement leakage, PINP, 25(OH)D, and BMD are closely associated with and are independent risk factors for secondary fractures after PVP/PKP in OTF patients. The nomogram model based on these factors has high value. Screening high-risk populations using these indicators provides crucial theoretical guidance for the clinical prevention and treatment of secondary fractures.

Indexed as

bone metabolismbone mineral densityosteoporotic thoracolumbar fracturepercutaneous kyphoplastypercutaneous vertebroplastysecondary fracture

Identifiers

PMID42597544

DOI10.3389/fsurg.2026.1730811

PMCPMC13468799

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