Evidence map›Paper›PMID 42597536›Full record

ArticleFrontiers in cellular and infection microbiology2026

Trem2 negatively regulates the MTOR-PKCα axis to protect against

Xiaoyu Geng, Yangchenxi Lu, Xinyi Zhou, Xiaoyao Xu, Yahan Liu, Junfang Zhang, Jinling Chen

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PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiaoyu Geng *Department of Pathogen Biology, School of Medicine, Nantong University, Nantong, China.
Yangchenxi Lu *Department of Pathogen Biology, School of Medicine, Nantong University, Nantong, China.
Xinyi Zhou *Department of Pathogen Biology, School of Medicine, Nantong University, Nantong, China.
Xiaoyao XuDepartment of Pathogen Biology, School of Medicine, Nantong University, Nantong, China.
Yahan LiuDepartment of Pathogen Biology, School of Medicine, Nantong University, Nantong, China.
Junfang ZhangEye Institute, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China.
Jinling ChenDepartment of Pathogen Biology, School of Medicine, Nantong University, Nantong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Triggering receptor expressed on myeloid cells 2 (Trem2) deficiency aggravated adverse pregnancy outcomes caused by Methods: Molecular docking, co-immunoprecipitation, and alanine scanning mutagenesis were employed to identify the interaction between Trem2 and mammalian target of rapamycin (MTOR). Results: A direct high-affinity interaction between Trem2 and MTOR was identified, with GLN-198, ARG-195, and LYS-199 as critical binding residues. Conclusion: Trem2 negatively regulates the MTOR-PKCα axis through direct interaction, and

Indexed as

Membrane GlycoproteinsProtein Kinase C-alphaReceptors, ImmunologicTOR Serine-Threonine KinasesToxoplasmaToxoplasmosisAnimalsDisease Models, AnimalFemaleMacrophagesMiceMice, KnockoutPregnancyPregnancy OutcomeRAW 264.7 CellsSignal TransductionMembrane GlycoproteinsmTOR protein, mouseProtein Kinase C-alphaReceptors, ImmunologicTOR Serine-Threonine KinasesTrem2 protein, mouseadverse pregnancy outcomesmTORPKCαToxoplasma gondiiTrem2

Identifiers

PMID42597536
PMCPMC13468792

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.