ArticleAmerican journal of cancer research2026
Raman microspectroscopy for cervical cancer diagnosis: an ex-vivo cryopreserved tissue analysis.
Article in American journal of cancer research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Cervical cancer was the fourth most common cancer worldwide in 2022. There is an urgent clinical need for new objective and reproductible methods aiming an early diagnosis. The aim of the present study is to characterize fresh cryopreserved human cervical tissue through Raman microspectroscopy to identify spectral biomarkers that highlight the chemical differences between healthy and malignant tissues. Normal and tumoral human cervical tissues samples were collected prospectively from patients and from pathology specimens and cryopreserved at -80°C without any treatment or cryoprotectant. Two parallel 10 µm sections were cut from each tissue block for histopathology and spectroscopy analysis. Raman microspectroscopy using a 532 nm laser was performed in the first minutes after defrosting the sample. Concerning the high-wavenumber region (2800-3600 cm
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