ArticleAmerican journal of cancer research2026
Predictive value of conventional ultrasonographic features combined with clinical factors for capsular invasion in papillary thyroid carcinoma with Hashimoto's thyroiditis.
Article in American journal of cancer research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This retrospective study aimed to investigate the predictive value of conventional ultrasonographic features combined with clinical factors for capsular invasion in patients with papillary thyroid carcinoma (PTC) with concurrent Hashimoto's thyroiditis (HT). A total of 262 patients with pathologically confirmed PTC and concurrent HT who underwent surgery at our institution from January 2018 to June 2024 were included as the training cohort. Patients were divided into capsular invasion and non-capsular invasion groups according to postoperative pathological findings. Clinical characteristics, conventional ultrasonographic features, and preoperative serum thyroid-stimulating hormone (TSH) levels were compared between the two groups. Univariate and multivariate logistic regression analyses were performed to identify independent predictors of capsular invasion, and a nomogram model was constructed based on the selected variables. The predictive performance of the model was evaluated using receiver operating characteristic curves, calibration curves, decision curve analysis, and clinical impact curves. Univariate analysis showed that age, tumor diameter, postoperative lymph node metastasis, lesion margin, and blood flow signal were significantly associated with capsular invasion. Multivariate logistic regression analysis further identified age ≥55 years, larger tumor diameter, ill-defined lesion margin, and abundant blood flow signal as independent predictors of capsular invasion. The combined nomogram model achieved an area under the curve of 0.706 in the training cohort and 0.804 in the external validation cohort, showing better predictive performance than any single factor alone. Calibration curves, decision curve analysis, and clinical impact curves suggested acceptable model calibration and potential clinical utility. These findings indicate that a nomogram incorporating age, tumor diameter, lesion margin, and blood flow signal may provide a practical preoperative tool for estimating the risk of capsular invasion in patients with PTC and HT.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.