ReviewFrontiers in radiology2026
Portal vein recanalization and transjugular intrahepatic portosystemic shunt in chronic portal vein thrombosis: a narrative review.
Review in Frontiers in radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Portal vein thrombosis (PVT) is a heterogeneous and clinically significant complication of liver cirrhosis, primary hepatobiliary malignancy, and various systemic prothrombotic states. It is associated with advanced portal hypertension, increased surgical complexity during liver transplantation, and higher mortality. The aim of this manuscript is to provide a narrative review of PVT and portal vein recanalization combined with transjugular intrahepatic portosystemic shunt (PVR-TIPS), detailing epidemiology, pathophysiology, and diagnostic classifications while exploring evolving medical and interventional management strategies. A comprehensive narrative review of the existing literature was conducted, incorporating clinical practice guidelines from major societies (AASLD, Baveno VII, EASL, and AGA) and recent prospective and retrospective studies regarding the management of non-malignant PVT in both cirrhotic and non-cirrhotic patients. PVT occurs in approximately 1% of the general population but affects up to 44% of candidates for liver transplantation (LT). Its development is governed by Virchow's triad, with reduced portal flow velocity (<15 cm/s) being the primary independent predictor in cirrhosis. Diagnosis relies on Doppler ultrasound as a first-line screening tool, followed by contrast-enhanced computed tomography or magnetic resonance imaging to define the degree of occlusion, extent, and chronicity using standardized nomenclature. Medical management with anticoagulation is the cornerstone for recent PVT (<6 months), achieving recanalization in 40%-75% of cases. For chronic obliterative PVT or refractory complications (variceal bleeding or refractory ascites), PVR-TIPS has emerged as a safe and highly successful intervention, with technical success rates ranging from 75% to 100% in expert centers. PVR-TIPS facilitates physiologic end-to-end portal anastomosis during LT in up to 96%-100% of cases, significantly improving transplant feasibility and outcomes. The management of PVT has transitioned toward highly individualized strategies. Standardized classification remains essential for guiding therapy. While medical management is effective for recent-onset disease, PVR-TIPS represents a transformative interventional advancement for chronic obliterative PVT, restoring physiologic flow and optimizing candidates for curative liver transplantation.
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