Evidence map›Paper›PMID 42597322›Full record

Trial reportMalawi medical journal : the journal of Medical Association of Malawi2026

Clinical effects of adjunctive spleen- and kidney-invigorating Chinese herbal therapy combined with highly active antiretroviral treatment on immune recovery and nutritional status in people living with HIV.

Lei Zhang, Yili Ren, Zhan Zhang, Beibei Zhang, Chenkai Xu

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Malawi medical journal : the journal of Medical Association of Malawi, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lei ZhangDepartment of Infectious Diseases/Department of hepatology I, Affiliated Hospital of Shaoxing University, Shaoxing 312000, Zhejiang, China.
Yili RenDepartment of Geriatrics II, Affiliated Hospital of Shaoxing University, Shaoxing 312000, Zhejiang, China.
Zhan ZhangDepartment of Infectious Diseases/Department of hepatology I, Affiliated Hospital of Shaoxing University, Shaoxing 312000, Zhejiang, China.
Beibei ZhangDepartment of Oncology, Zhejiang Hospital, Hangzhou 310013, Zhejiang, China.
Chenkai XuDepartment of Cardiology, Zhejiang Hospital, Hangzhou 310013, Zhejiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To evaluate whether adding a spleen- and kidney-invigorating Chinese herbal decoction to highly active antiretroviral therapy (HAART) improves immune recovery and nutritional status in people living with HIV. Methods: Forty adults living with HIV were randomly allocated to receive either standard HAART alone or HAART plus a Chinese herbal decoction composed of astragalus, Chinese yam, dangshen, poria cocos, white atractylodes rhizome, radix pseudostellariae, and rehmannia glutinosa. Immune indices (CD4 Results: Compared with HAART alone, HAART plus Chinese herbal decoction produced more marked immune reconstitution. At 6-12 months, the combination group had higher CD4 Conclusion: Adjunctive use of a spleen- and kidney-invigorating Chinese herbal decoction with HAART may help restore the balance of T-lymphocyte subsets, attenuate systemic inflammation, enhance immune function, and improve nutritional status in patients with acquired immune deficiency syndrome.

Indexed as

Anti-HIV AgentsAntiretroviral Therapy, Highly ActiveDrugs, Chinese HerbalHIV InfectionsNutritional StatusAdultCD4 Lymphocyte CountFemaleHumansMaleMiddle AgedSpleenTreatment OutcomeTumor Necrosis Factor-alphaAnti-HIV AgentsDrugs, Chinese HerbalTumor Necrosis Factor-alphaAcquired Immune Deficiency SyndromeChinese Traditional MedicineHighly Active Antiretroviral TherapyNutritional StatusT Lymphocyte Subsets

Identifiers

PMID42597322
PMCPMC13458993

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.